Seroatlas · Human Serome Atlas

TMEM140

Transmembrane protein 140

Also known as: FLJ11000, TM140_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NV12
Gene
TMEM140
Ensembl
ENSG00000146859
Chromosome
7
Canonical length
185 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>Q9NV12|TMEM140
     1  MAGPRPRWRD QLLFMSIIVL VIVVICLMFY ALLWEAGNLT DLPNLRIGFY NFCLWNEDTS
    61  TLQCHQFPEL EALGVPRVGL GLARLGVYGS LVLTLFAPQP LLLAQCNSDE RAWRLAVGFL
   121  AVSSVLLAGG LGLFLSYVWK WVRLSLPGPG FLALGSAQAL LILLLIAMAV FPLRAERAES
   181  KLESC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM140 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
84 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 84 nTPM
  • liver: 51 nTPM
  • adipose tissue: 35 nTPM
  • lung: 29 nTPM
  • heart muscle: 29 nTPM
  • breast: 27 nTPM

Single-cell type

  • platelets: 1,010 nCPM
  • neutrophils: 177 nCPM
  • plasma cells: 100 nCPM
  • syncytiotrophoblasts: 84 nCPM
  • lymphatic endothelial cells: 78 nCPM
  • epicardial cells: 59 nCPM

Immune cell

  • neutrophil: 431 nTPM
  • basophil: 360 nTPM
  • eosinophil: 109 nTPM
  • total PBMC: 64 nTPM
  • T-reg: 51 nTPM
  • naive B-cell: 46 nTPM

Brain region

  • white matter: 62 nTPM
  • medulla oblongata: 56 nTPM
  • basal ganglia: 39 nTPM
  • pons: 39 nTPM
  • cerebellum: 37 nTPM
  • midbrain: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0.05
gnomAD missense Z
0.07
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • TM140 protein family
  • TM140 protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM140 as an antibody target. Whether an autoantibody or antibody against TMEM140 could matter depends on whether native TMEM140 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM140 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM140 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM140. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...