Seroatlas · Human Serome Atlas

TMEM139

Transmembrane protein 139

Also known as: FLJ90586, TM139_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IV31
Gene: TMEM139
Ensembl: ENSG00000178826
Chromosome: 7
Canonical length: 216 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Focal adhesion sites

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>Q8IV31|TMEM139
     1  MVPMHLLGRL EKPLLLLCCA SFLLGLALLG IKTDITPVAY FFLTLGGFFL FAYLLVRFLE
    61  WGLRSQLQSM QTESPGPSGN ARDNEAFEVP VYEEAVVGLE SQCRPQELDQ PPPYSTVVIP
   121  PAPEEEQPSH PEGSRRAKLE QRRMASEGSM AQEGSPGRAP INLRLRGPRA VSTAPDLQSL
   181  AAVPTLEPLT PPPAYDVCFG HPDDDSVFYE DNWAPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM139 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

duodenum: 32 nTPM
kidney: 30 nTPM
small intestine: 18 nTPM
spinal cord: 15 nTPM
liver: 9 nTPM
cervix: 8.4 nTPM

Single-cell type

enterocytes: 81 nCPM
endometrial secretory cells: 43 nCPM
alveolar cells type 1: 41 nCPM
colonocytes: 41 nCPM
cytotrophoblasts: 37 nCPM
breast myoepithelial cells: 30 nCPM

Immune cell

intermediate monocyte: 0.8 nTPM
non-classical monocyte: 0.8 nTPM
T-reg: 0.6 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
eosinophil: 0.2 nTPM

Brain region

white matter: 30 nTPM
medulla oblongata: 25 nTPM
pons: 19 nTPM
midbrain: 17 nTPM
cerebellum: 17 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0.01
gnomAD missense Z: -0.21
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 139

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM139 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SLC4A1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM139 as an antibody target. Whether an autoantibody or antibody against TMEM139 could matter depends on whether native TMEM139 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM139 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM139 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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