Seroatlas · Human Serome Atlas

TMEM135

Transmembrane protein 135

Also known as: FLJ22104, TM135_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UB9
Gene
TMEM135
Ensembl
ENSG00000166575
Chromosome
11
Canonical length
458 aa
Protein class
Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to enable lipid transporter activity. Predicted to be involved in several processes, including fatty acid derivative transport; fatty acid metabolic process; and long-chain fatty acid transport. Predicted to act upstream of or within several processes, including regulation of oxidative phosphorylation; response to food; and retinal pigment epithelium development. Predicted to be located in peroxisome. Predicted to be active in peroxisomal membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q86UB9|TMEM135
     1  MAALSKSIPH NCYEIGHTWH PSCRVSFLQI TGGALEESLK IYAPLYLIAA ILRKRKLDYY
    61  LHKLLPEILQ SASFLTANGA LYMAFFCILR KILGKFYSWT PGFGAALPAS YVAILIERKS
   121  RRGLLTIYMA NLATETLFRM GVARGTITTL RNGEVLLFCI TAAMYMFFFR CKDGLKGFTF
   181  SALRFIVGKE EIPTHSFSPE AAYAKVEQKR EQHEEKPGRM NMIGLVRKFV DSICKHGPRH
   241  RCCKHYEDNC ISYCIKGFIR MFSVGYLIQC CLRIPSAFRH LFTQPSRLLS LFYNKENFQL
   301  GAFLGSFVSI YKGTSCFLRW IRNLDDELHA IIAGFLAGIS MMFYKSTTIS MYLASKLVET
   361  MYFKGIEAGK VPYFPHADTI IYSISTAICF QAAVMEVQTL RPSYWKFLLR LTKGKFAVMN
   421  RKVLDVFGTG ASKHFQDFIP RLDPRYTTVT PELPTEFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM135 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 25 nTPM
  • liver: 23 nTPM
  • duodenum: 15 nTPM
  • adrenal gland: 14 nTPM
  • small intestine: 14 nTPM
  • breast: 13 nTPM

Single-cell type

  • adipocytes: 783 nCPM
  • sertoli cells: 561 nCPM
  • fibro-adipogenic progenitors: 303 nCPM
  • adrenal cortex cells: 298 nCPM
  • pituitary stem cells: 290 nCPM
  • thyrotrophs: 276 nCPM

Immune cell

  • memory CD8 T-cell: 8.1 nTPM
  • gdT-cell: 7.6 nTPM
  • NK-cell: 7.2 nTPM
  • MAIT T-cell: 6.8 nTPM
  • myeloid DC: 5.7 nTPM
  • plasmacytoid DC: 5.7 nTPM

Brain region

  • midbrain: 36 nTPM
  • white matter: 35 nTPM
  • basal ganglia: 35 nTPM
  • choroid plexus: 34 nTPM
  • pons: 34 nTPM
  • hypothalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.78
gnomAD missense Z
1.56
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Tim17/Tim22/Tim23/Pmp24 family
  • Transmembrane protein 135
  • Transmembrane protein 135, N-terminal domain
  • N-terminal cysteine-rich region of Transmembrane protein 135

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM135 as an antibody target. Whether an autoantibody or antibody against TMEM135 could matter depends on whether native TMEM135 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM135 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM135 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM135. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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