Seroatlas · Human Serome Atlas

TMEM134

Transmembrane protein 134

Also known as: FLJ21749, TM134_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6X4
Gene: TMEM134
Ensembl: ENSG00000172663
Chromosome: 11
Canonical length: 195 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

Located in cytosol and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q9H6X4|TMEM134
     1  MSAARPQFSI DDAFELSLED GGPGPESSGV ARFGPLHFER RARFEVADED KQSRLRYQNL
    61  ENDEDGAQAS PEPDGGVGTR DSSRTSIRSS QWSFSTISSS TQRSYNTCCS WTQHPLIQKN
   121  RRVVLASFLL LLLGLVLILV GVGLEATPSP GVSSAIFFVP GFLLLVPGVY HVIFIYCAVK
   181  GHRGFQFFYL PYFEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM134 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 57 nTPM
skin: 56 nTPM
esophagus: 55 nTPM
heart muscle: 46 nTPM
pancreas: 42 nTPM
liver: 34 nTPM

Single-cell type

esophageal apical cells: 873 nCPM
esophageal suprabasal cells: 584 nCPM
esophageal basal cells: 296 nCPM
suprabasal keratinocytes: 230 nCPM
extravillous trophoblasts: 219 nCPM
epididymal principal cells: 213 nCPM

Immune cell

memory B-cell: 205 nTPM
naive B-cell: 197 nTPM
non-classical monocyte: 177 nTPM
intermediate monocyte: 133 nTPM
T-reg: 124 nTPM
eosinophil: 99 nTPM

Brain region

basal ganglia: 18 nTPM
thalamus: 17 nTPM
cerebral cortex: 17 nTPM
medulla oblongata: 17 nTPM
spinal cord: 17 nTPM
midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM134 as an antibody target. Whether an autoantibody or antibody against TMEM134 could matter depends on whether native TMEM134 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM134 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM134 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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