Seroatlas · Human Serome Atlas

TMEM132E-DT

Uncharacterized protein TMEM132E-DT

Also known as: CQ102_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2RUQ5
Gene: TMEM132E-DT
Canonical length: 167 aa

OverviewNCBI Gene

No narrative summary is available for TMEM132E-DT in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>A2RUQ5|TMEM132E-DT
     1  MFDFSFPTPA SAGTRMGPAS CGGRSLHLPQ LRFSRVDATA VTDVPFQRMH APHRAPEVFC
    61  SRSSRGAGRG HPTPTPRVRW ALAGNQPRCC AQLLSGRGGS GAQLRAGWVR GAAVGNLFIL
   121  LLGKEDGEEE GTVLSYSSMV HISNITGIVG TTVSRTKPAL VLMELTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM132E-DT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM132E-DT as an antibody target. Whether an autoantibody or antibody against TMEM132E-DT could matter depends on whether native TMEM132E-DT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM132E-DT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM132E-DT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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