Seroatlas · Human Serome Atlas

TMEM131

Transmembrane protein 131

Also known as: CC28, KIAA0257, PRO1048, RW1, TM131_HUMAN, YR-23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92545
Gene: TMEM131
Ensembl: ENSG00000075568
Chromosome: 2
Canonical length: 1883 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Intermediate filaments

OverviewNCBI Gene

Enables collagen binding activity. Involved in collagen biosynthetic process. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1883 residues, UniProt reviewed canonical sequence.

>Q92545|TMEM131
     1  MGKRAGGGAT GATTAAVSTS AGAGLEPAAA RSGGPRSAAA GLLGALHLVM TLVVAAARAE
    61  KEAFVQSESI IEVLRFDDGG LLQTETTLGL SSYQQKSISL YRGNCRPIRF EPPMLDFHEQ
   121  PVGMPKMEKV YLHNPSSEET ITLVSISATT SHFHASFFQN RKILPGGNTS FDVVFLARVV
   181  GNVENTLFIN TSNHGVFTYQ VFGVGVPNPY RLRPFLGARV PVNSSFSPII NIHNPHSEPL
   241  QVVEMYSSGG DLHLELPTGQ QGGTRKLWEI PPYETKGVMR ASFSSREADN HTAFIRIKTN
   301  ASDSTEFIIL PVEVEVTTAP GIYSSTEMLD FGTLRTQDLP KVLNLHLLNS GTKDVPITSV
   361  RPTPQNDAIT VHFKPITLKA SESKYTKVAS ISFDASKAKK PSQFSGKITV KAKEKSYSKL
   421  EIPYQAEVLD GYLGFDHAAT LFHIRDSPAD PVERPIYLTN TFSFAILIHD VLLPEEAKTM
   481  FKVHNFSKPV LILPNESGYI FTLLFMPSTS SMHIDNNILL ITNASKFHLP VRVYTGFLDY
   541  FVLPPKIEER FIDFGVLSAT EASNILFAII NSNPIELAIK SWHIIGDGLS IELVAVERGN
   601  RTTIISSLPE FEKSSLSDQS SVTLASGYFA VFRVKLTAKK LEGIHDGAIQ ITTDYEILTI
   661  PVKAVIAVGS LTCFPKHVVL PPSFPGKIVH QSLNIMNSFS QKVKIQQIRS LSEDVRFYYK
   721  RLRGNKEDLE PGKKSKIANI YFDPGLQCGD HCYVGLPFLS KSEPKVQPGV AMQEDMWDAD
   781  WDLHQSLFKG WTGIKENSGH RLSAIFEVNT DLQKNIISKI TAELSWPSIL SSPRHLKFPL
   841  TNTNCSSEEE ITLENPADVP VYVQFIPLAL YSNPSVFVDK LVSRFNLSKV AKIDLRTLEF
   901  QVFRNSAHPL QSSTGFMEGL SRHLILNLIL KPGEKKSVKV KFTPVHNRTV SSLIIVRNNL
   961  TVMDAVMVQG QGTTENLRVA GKLPGPGSSL RFKITEALLK DCTDSLKLRE PNFTLKRTFK
  1021  VENTGQLQIH IETIEISGYS CEGYGFKVVN CQEFTLSANA SRDIIILFTP DFTASRVIRE
  1081  LKFITTSGSE FVFILNASLP YHMLATCAEA LPRPNWELAL YIIISGIMSA LFLLVIGTAY
  1141  LEAQGIWEPF RRRLSFEASN PPFDVGRPFD LRRIVGISSE GNLNTLSCDP GHSRGFCGAG
  1201  GSSSRPSAGS HKQCGPSVHP HSSHSNRNSA DVENVRAKNS SSTSSRTSAQ AASSQSANKT
  1261  SPLVLDSNTV TQGHTAGRKS KGAKQSQHGS QHHAHSPLEQ HPQPPLPPPV PQPQEPQPER
  1321  LSPAPLAHPS HPERASSARH SSEDSDITSL IEAMDKDFDH HDSPALEVFT EQPPSPLPKS
  1381  KGKGKPLQRK VKPPKKQEEK EKKGKGKPQE DELKDSLADD DSSSTTTETS NPDTEPLLKE
  1441  DTEKQKGKQA MPEKHESEMS QVKQKSKKLL NIKKEIPTDV KPSSLELPYT PPLESKQRRN
  1501  LPSKIPLPTA MTSGSKSRNA QKTKGTSKLV DNRPPALAKF LPNSQELGNT SSSEGEKDSP
  1561  PPEWDSVPVH KPGSSTDSLY KLSLQTLNAD IFLKQRQTSP TPASPSPPAA PCPFVARGSY
  1621  SSIVNSSSSS DPKIKQPNGS KHKLTKAASL PGKNGNPTFA AVTAGYDKSP GGNGFAKVSS
  1681  NKTGFSSSLG ISHAPVDSDG SDSSGLWSPV SNPSSPDFTP LNSFSAFGNS FNLTGEVFSK
  1741  LGLSRSCNQA SQRSWNEFNS GPSYLWESPA TDPSPSWPAS SGSPTHTATS VLGNTSGLWS
  1801  TTPFSSSIWS SNLSSALPFT TPANTLASIG LMGTENSPAP HAPSTSSPAD DLGQTYNPWR
  1861  IWSPTIGRRS SDPWSNSHFP HEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM131 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 26 nTPM
stomach: 25 nTPM
colon: 24 nTPM
lymph node: 24 nTPM
skeletal muscle: 23 nTPM
skin: 23 nTPM

Single-cell type

myonuclei: 607 nCPM
b-cells: 381 nCPM
neutrophil progenitors: 370 nCPM
thyrotrophs: 284 nCPM
neutrophils: 274 nCPM
cardiomyocytes: 267 nCPM

Immune cell

basophil: 3.7 nTPM
eosinophil: 3.6 nTPM
NK-cell: 2.5 nTPM
plasmacytoid DC: 2.4 nTPM
naive CD8 T-cell: 2.3 nTPM
memory B-cell: 2.1 nTPM

Brain region

thalamus: 36 nTPM
choroid plexus: 35 nTPM
white matter: 32 nTPM
cerebral cortex: 32 nTPM
midbrain: 31 nTPM
basal ganglia: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 2.08
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin-like fold
Transmembrane protein 131-like, N-terminal
Transmembrane protein 131-like
Transmembrane protein 131-like, second Ig-like domain
TMEM131L, third Ig-like domain
TMEM131L, fourth Ig-like domain
TMEM131L, fifth Ig-like domain
Transmembrane protein 131-like N-terminal
Transmembrane protein 131-like, second Ig-like domain
TMEM131L third Ig-like domain
TMEM131L fourth Ig-like domain
TMEM131L fifth Ig-like domain
TMEM131, second Ig-like domain
Transmembrane protein 131 second Ig-like domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM131 as an antibody target. Whether an autoantibody or antibody against TMEM131 could matter depends on whether native TMEM131 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM131 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM131 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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