Seroatlas · Human Serome Atlas

TMEM130

Transmembrane protein 130

Also known as: DKFZp761L1417, FLJ42643, TM130_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3G9
Gene: TMEM130
Ensembl: ENSG00000166448
Chromosome: 7
Canonical length: 435 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>Q8N3G9|TMEM130
     1  MAQAVWSRLG RILWLACLLP WAPAGVAAGL YELNLTTDSP ATTGAVVTIS ASLVAKDNGS
    61  LALPADAHLY RFHWIHTPLV LTGKMEKGLS STIRVVGHVP GEFPVSVWVT AADCWMCQPV
   121  ARGFVVLPIT EFLVGDLVVT QNTSLPWPSS YLTKTVLKVS FLLHDPSNFL KTALFLYSWD
   181  FGDGTQMVTE DSVVYYNYSI IGTFTVKLKV VAEWEEVEPD ATRAVKQKTG DFSASLKLQE
   241  TLRGIQVLGP TLIQTFQKMT VTLNFLGSPP LTVCWRLKPE CLPLEEGECH PVSVASTAYN
   301  LTHTFRDPGD YCFSIRAENI ISKTHQYHKI QVWPSRIQPA VFAFPCATLI TVMLAFIMYM
   361  TLRNATQQKD MVEVADFDFS PMSDKNPEPP SGVRCCCQMC CGPFLLETPS EYLEIVRENH
   421  GLLPPLYKSV KTYTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM130 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 167 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 167 nTPM
cerebral cortex: 150 nTPM
basal ganglia: 139 nTPM
hippocampal formation: 97 nTPM
pituitary gland: 95 nTPM
amygdala: 82 nTPM

Single-cell type

corticotrophs: 228 nCPM
adrenal medulla cells: 160 nCPM
other brain neurons: 143 nCPM
lactotrophs: 141 nCPM
thyrotrophs: 133 nCPM
somatotrophs: 125 nCPM

Immune cell

neutrophil: 1.3 nTPM
basophil: 0.7 nTPM
NK-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
eosinophil: 0.2 nTPM
memory B-cell: 0.2 nTPM

Brain region

hypothalamus: 477 nTPM
cerebral cortex: 414 nTPM
basal ganglia: 304 nTPM
hippocampal formation: 295 nTPM
white matter: 257 nTPM
amygdala: 241 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM130 as an antibody target. Whether an autoantibody or antibody against TMEM130 could matter depends on whether native TMEM130 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM130 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM130 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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