Seroatlas · Human Serome Atlas

TMEM129

E3 ubiquitin-protein ligase TM129

Also known as: D4S2561E, TM129_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0AVI4
Gene: TMEM129
Ensembl: ENSG00000168936
Chromosome: 4
Canonical length: 362 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in protein polyubiquitination; retrograde protein transport, ER to cytosol; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>A0AVI4|TMEM129
     1  MDSPEVTFTL AYLVFAVCFV FTPNEFHAAG LTVQNLLSGW LGSEDAAFVP FHLRRTAATL
    61  LCHSLLPLGY YVGMCLAASE KRLHALSQAP EAWRLFLLLA VTLPSIACIL IYYWSRDRWA
   121  CHPLARTLAL YALPQSGWQA VASSVNTEFR RIDKFATGAP GARVIVTDTW VMKVTTYRVH
   181  VAQQQDVHLT VTESRQHELS PDSNLPVQLL TIRVASTNPA VQAFDIWLNS TEYGELCEKL
   241  RAPIRRAAHV VIHQSLGDLF LETFASLVEV NPAYSVPSSQ ELEACIGCMQ TRASVKLVKT
   301  CQEAATGECQ QCYCRPMWCL TCMGKWFASR QDPLRPDTWL ASRVPCPTCR ARFCILDVCT
   361  VR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM129 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

liver: 46 nTPM
kidney: 42 nTPM
pituitary gland: 42 nTPM
basal ganglia: 39 nTPM
heart muscle: 37 nTPM
pancreas: 35 nTPM

Single-cell type

epididymal principal cells: 43 nCPM
esophageal basal cells: 39 nCPM
enteric transient amplifying cells: 38 nCPM
peritubular myoid cells: 36 nCPM
müller glia: 35 nCPM
enteric stem cells: 34 nCPM

Immune cell

plasmacytoid DC: 3.7 nTPM
classical monocyte: 1.7 nTPM
gdT-cell: 1.6 nTPM
myeloid DC: 1.6 nTPM
MAIT T-cell: 1.4 nTPM
memory CD4 T-cell: 1.4 nTPM

Brain region

choroid plexus: 55 nTPM
medulla oblongata: 51 nTPM
spinal cord: 48 nTPM
midbrain: 47 nTPM
thalamus: 46 nTPM
basal ganglia: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

E3 ubiquitin-protein ligase TM129
Putative transmembrane protein precursor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM129 as an antibody target. Whether an autoantibody or antibody against TMEM129 could matter depends on whether native TMEM129 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM129 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM129 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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