Seroatlas · Human Serome Atlas

TMEM128

Transmembrane protein 128

Also known as: MGC13159, TM128_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5BJH2
Gene
TMEM128
Ensembl
ENSG00000132406
Chromosome
4
Canonical length
165 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>Q5BJH2|TMEM128
     1  MDSSRARQQL RRRFLLLPDA EAQLDREGDA GPETSTAVEK KEKPLPRLNI HSGFWILASI
    61  VVTYYVDFFK TLKENFHTSS WFLCGSALLL VSLSIAFYCI VYLEWYCGIG EYDVKYPALI
   121  PITTASFIAA GICFNIALWH VWSFFTPLLL FTQFMGVVMF ITLLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM128 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 44 nTPM
  • spinal cord: 44 nTPM
  • parathyroid gland: 42 nTPM
  • ovary: 35 nTPM
  • thyroid gland: 35 nTPM
  • kidney: 31 nTPM

Single-cell type

  • parietal cells: 92 nCPM
  • early primary spermatocytes: 81 nCPM
  • extravillous trophoblasts: 60 nCPM
  • late primary spermatocytes: 58 nCPM
  • cytotrophoblasts: 56 nCPM
  • decidual stromal cells: 55 nCPM

Immune cell

  • plasmacytoid DC: 62 nTPM
  • naive CD4 T-cell: 59 nTPM
  • intermediate monocyte: 51 nTPM
  • naive CD8 T-cell: 50 nTPM
  • MAIT T-cell: 46 nTPM
  • NK-cell: 46 nTPM

Brain region

  • white matter: 33 nTPM
  • medulla oblongata: 26 nTPM
  • spinal cord: 24 nTPM
  • cerebellum: 22 nTPM
  • hypothalamus: 22 nTPM
  • basal ganglia: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.62
gnomAD pLI
0
gnomAD missense Z
0.38
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 128
  • TMEM128 protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM128 as an antibody target. Whether an autoantibody or antibody against TMEM128 could matter depends on whether native TMEM128 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM128 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM128 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM128. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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