Seroatlas · Human Serome Atlas

TMEM125

Transmembrane protein 125

Also known as: MGC17299, TM125_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96AQ2
Gene
TMEM125
Ensembl
ENSG00000179178
Chromosome
1
Canonical length
219 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Midbody,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q96AQ2|TMEM125
     1  MSEQEAQAPG GRGLPPDMLA EQVELWWSQQ PRRSALCFVV AVGLVAGCGA GGVALLSTTS
    61  SRSGEWRLAT GTVLCLLALL VLVKQLMSSA VQDMNCIRQA HHVALLRSGG GADALVVLLS
   121  GLVLLVTGLT LAGLAAAPAP ARPLAAMLSV GIALAALGSL LLLGLLLYQV GVSGHCPSIC
   181  MATPSTHSGH GGHGSIFSIS GQLSAGRRHE TTSSIASLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM125 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
86 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 86 nTPM
  • lung: 71 nTPM
  • spinal cord: 64 nTPM
  • thyroid gland: 43 nTPM
  • duodenum: 33 nTPM
  • midbrain: 32 nTPM

Single-cell type

  • alveolar cells type 2: 197 nCPM
  • alveolar cells type 1: 155 nCPM
  • enterocytes: 147 nCPM
  • transitional alveolar cells: 123 nCPM
  • breast lactating cells: 94 nCPM
  • oligodendrocytes: 86 nCPM

Immune cell

  • NK-cell: 0.3 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • white matter: 71 nTPM
  • medulla oblongata: 49 nTPM
  • basal ganglia: 48 nTPM
  • midbrain: 41 nTPM
  • cerebellum: 39 nTPM
  • thalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.97
gnomAD pLI
0
gnomAD missense Z
0.54
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • TMEM125 protein family
  • TMEM125 protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM125 as an antibody target. Whether an autoantibody or antibody against TMEM125 could matter depends on whether native TMEM125 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM125 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM125 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM125. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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