Seroatlas · Human Serome Atlas

TMEM119

Transmembrane protein 119

Also known as: OBIF, TM119_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4V9L6
Gene: TMEM119
Ensembl: ENSG00000183160
Chromosome: 12
Canonical length: 283 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins, Transporters
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Involved in positive regulation of bone mineralization; positive regulation of osteoblast differentiation; and positive regulation of osteoblast proliferation. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>Q4V9L6|TMEM119
     1  MVSAAAPSLL ILLLLLLGSV PATDARSVPL KATFLEDVAG SGEAEGSSAS SPSLPPPWTP
    61  ALSPTSMGPQ PITLGGPSPP TNFLDGIVDF FRQYVMLIAV VGSLAFLLMF IVCAAVITRQ
   121  KQKASAYYPS SFPKKKYVDQ SDRAGGPRAF SEVPDRAPDS RPEEALDSSR QLQADILAAT
   181  QNLKSPTRAA LGGGDGARMV EGRGAEEEEK GSQEGDQEVQ GHGVPVETPE AQEEPCSGVL
   241  EGAVVAGEGQ GELEGSLLLA QEAQGPVGPP ESPCACSSVH PSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM119 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

cervix: 57 nTPM
lymph node: 45 nTPM
lung: 36 nTPM
gallbladder: 34 nTPM
urinary bladder: 30 nTPM
adipose tissue: 29 nTPM

Single-cell type

microglia: 58 nCPM
fibroblasts: 31 nCPM
pericytes: 29 nCPM
peritubular myoid cells: 28 nCPM
neutrophils: 15 nCPM
hepatic stellate cells: 13 nCPM

Immune cell

neutrophil: 1.4 nTPM
basophil: 1.2 nTPM
memory CD4 T-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM
non-classical monocyte: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM

Brain region

white matter: 53 nTPM
medulla oblongata: 42 nTPM
thalamus: 40 nTPM
pons: 36 nTPM
spinal cord: 35 nTPM
midbrain: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.63
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 119
TMEM119 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM119 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM119 as an antibody target. Whether an autoantibody or antibody against TMEM119 could matter depends on whether native TMEM119 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM119 is annotated at the cell surface, where native TMEM119 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM119 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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