Seroatlas · Human Serome Atlas

TMEM117

Transmembrane protein 117

Also known as: DKFZp434K2435, TM117_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0C3
Gene: TMEM117
Ensembl: ENSG00000139173
Chromosome: 12
Canonical length: 514 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>Q9H0C3|TMEM117
     1  MGKDFRYYFQ HPWSRMIVAY LVIFFNFLIF AEDPVSHSQT EANVIVVGNC FSFVTNKYPR
    61  GVGWRILKVL LWLLAILTGL IAGKFLFHQR LFGQLLRLKM FREDHGSWMT MFFSTILFLF
   121  IFSHIYNTIL LMDGNMGAYI ITDYMGIRNE SFMKLAAVGT WMGDFVTAWM VTDMMLQDKP
   181  YPDWGKSARA FWKKGNVRIT LFWTVLFTLT SVVVLVITTD WISWDKLNRG FLPSDEVSRA
   241  FLASFILVFD LLIVMQDWEF PHFMGDVDVN LPGLHTPHMQ FKIPFFQKIF KEEYRIHITG
   301  KWFNYGIIFL VLILDLNMWK NQIFYKPHEY GQYIGPGQKI YTVKDSESLK DLNRTKLSWE
   361  WRSNHTNPRT NKTYVEGDMF LHSRFIGASL DVKCLAFVPS LIAFVWFGFF IWFFGRFLKN
   421  EPRMENQDKT YTRMKRKSPS EHSKDMGITR ENTQASVEDP LNDPSLVCIR SDFNEIVYKS
   481  SHLTSENLSS QLNESTSATE ADQDPTTSKS TPTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM117 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

duodenum: 5.7 nTPM
esophagus: 5.4 nTPM
seminal vesicle: 4.9 nTPM
heart muscle: 3.9 nTPM
small intestine: 3.9 nTPM
parathyroid gland: 3.8 nTPM

Single-cell type

renal collecting duct intercalated cells: 1,894 nCPM
choroid plexus epithelial cells: 1,748 nCPM
corticotrophs: 1,119 nCPM
gonadotrophs: 1,028 nCPM
thyrotrophs: 712 nCPM
respiratory ionocytes: 508 nCPM

Immune cell

MAIT T-cell: 1.8 nTPM
gdT-cell: 1.2 nTPM
memory CD8 T-cell: 1.2 nTPM
memory B-cell: 1 nTPM
naive B-cell: 0.9 nTPM
naive CD8 T-cell: 0.6 nTPM

Brain region

choroid plexus: 20 nTPM
pons: 6.8 nTPM
white matter: 6.2 nTPM
medulla oblongata: 5.2 nTPM
cerebellum: 4.1 nTPM
cerebral cortex: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 1.56
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular components

Protein domainsUniProt · Pfam · InterPro

TMEM117 protein
TMEM117 protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM117 as an antibody target. Whether an autoantibody or antibody against TMEM117 could matter depends on whether native TMEM117 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM117 is annotated at the cell surface, where native TMEM117 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM117 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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