Seroatlas · Human Serome Atlas

TMEM108

Transmembrane protein 108

Also known as: CT124, MGC3040, TM108_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXF1
Gene
TMEM108
Ensembl
ENSG00000144868
Chromosome
3
Canonical length
575 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli,Vesicles,Plasma membrane,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Predicted to be located in somatodendritic compartment. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q6UXF1|TMEM108
     1  MKRSLQALYC QLLSFLLILA LTEALAFAIQ EPSPRESLQV LPSGTPPGTM VTAPHSSTRH
    61  TSVVMLTPNP DGPPSQAAAP MATPTPRAEG HPPTHTISTI AATVTAPHSE SSLSTGPAPA
   121  AMATTSSKPE GRPRGQAAPT ILLTKPPGAT SRPTTAPPRT TTRRPPRPPG SSRKGAGNSS
   181  RPVPPAPGGH SRSKEGQRGR NPSSTPLGQK RPLGKIFQIY KGNFTGSVEP EPSTLTPRTP
   241  LWGYSSSPQP QTVAATTVPS NTSWAPTTTS LGPAKDKPGL RRAAQGGGST FTSQGGTPDA
   301  TAASGAPVSP QAAPVPSQRP HHGDPQDGPS HSDSWLTVTP GTSRPLSTSS GVFTAATGPT
   361  PAAFDTSVSA PSQGIPQGAS TTPQAPTHPS RVSESTISGA KEETVATLTM TDRVPSPLST
   421  VVSTATGNFL NRLVPAGTWK PGTAGNISHV AEGDKPQHRA TICLSKMDIA WVILAISVPI
   481  SSCSVLLTVC CMKRKKKTAN PENNLSYWNN TITMDYFNRH AVELPREIQS LETSEDQLSE
   541  PRSPANGDYR DTGMVLVNPF CQETLFVGND QVSEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM108 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • retina: 32 nTPM
  • skeletal muscle: 22 nTPM
  • testis: 13 nTPM
  • cerebral cortex: 12 nTPM
  • adrenal gland: 11 nTPM
  • lung: 9.7 nTPM

Single-cell type

  • rod photoreceptor cells: 2,247 nCPM
  • cone photoreceptor cells: 2,027 nCPM
  • bergmann glia: 1,264 nCPM
  • oligodendrocytes: 775 nCPM
  • oligodendrocyte progenitor cells: 637 nCPM
  • adrenal cortex cells: 550 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 46 nTPM
  • basal ganglia: 44 nTPM
  • thalamus: 42 nTPM
  • amygdala: 39 nTPM
  • pons: 34 nTPM
  • choroid plexus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
0.67
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 108
  • TMEM108 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM108 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM108 as an antibody target. Whether an autoantibody or antibody against TMEM108 could matter depends on whether native TMEM108 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM108 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM108 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM108. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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