Seroatlas · Human Serome Atlas

TMEM105

Transmembrane protein 105

Also known as: TM105_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8V8
Gene: TMEM105
Canonical length: 129 aa

OverviewNCBI Gene

No narrative summary is available for TMEM105 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

129 residues, UniProt reviewed canonical sequence.

>Q8N8V8|TMEM105
     1  MLLKVRRASL KPPATPHQGA FRAGNVIGQL IYLLTWSLFT AWLRPPTLLQ GPRTSPQGSP
    61  PRSPWGDCAE PSCLCEMKIR RRRHEGPAWG QSGFLAGGLH LVPSSLSLAA CGVVRMKGLW
   121  GRGAGIRGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM105 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.69

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0.01
gnomAD missense Z: -0.14

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM105 as an antibody target. Whether an autoantibody or antibody against TMEM105 could matter depends on whether native TMEM105 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM105 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM105 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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