Seroatlas · Human Serome Atlas

TMEM104

Transmembrane protein 104

Also known as: FLJ00021, FLJ20255, TM104_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NE00
Gene: TMEM104
Ensembl: ENSG00000109066
Chromosome: 17
Canonical length: 496 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q8NE00|TMEM104
     1  MAGEITETGE LYSSYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV FLGFMSFVTT
    61  TFVIEAMAAA NAQLHWKRME NLKEEEDDDS STASDSDVLI RDNYERAEKR PILSVQRRGS
   121  PNPFEITDRV EMGQMASMFF NKVGVNLFYF CIIVYLYGDL AIYAAAVPFS LMQVTCSATG
   181  NDSCGVEADT KYNDTDRCWG PLRRVDAYRI YLAIFTLLLG PFTFFDVQKT KYLQILTSLM
   241  RWIAFAVMIV LALIRIGHGQ GEGHPPLADF SGVRNLFGVC VYSFMCQHSL PSLITPVSSK
   301  RHLTRLVFLD YVLILAFYGL LSFTAIFCFR GDSLMDMYTL NFARCDVVGL AAVRFFLGLF
   361  PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRVVF PTITLVPPVL VAFCTHDLES
   421  LVGITGAYAG TGIQYVIPAF LVYHCRRDTQ LAFGCGVSNK HRSPFRHTFW VGFVLLWAFS
   481  CFIFVTANII LSETKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM104 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

liver: 15 nTPM
spinal cord: 13 nTPM
adrenal gland: 10 nTPM
pituitary gland: 9.9 nTPM
testis: 8.3 nTPM
bone marrow: 8 nTPM

Single-cell type

platelets: 65 nCPM
hofbauer cells: 49 nCPM
monocytes: 41 nCPM
endometrial luminal cells: 39 nCPM
breast lactating cells: 35 nCPM
monocyte progenitors: 31 nCPM

Immune cell

plasmacytoid DC: 5.6 nTPM
myeloid DC: 5.3 nTPM
classical monocyte: 5 nTPM
T-reg: 5 nTPM
gdT-cell: 4.7 nTPM
non-classical monocyte: 4.6 nTPM

Brain region

medulla oblongata: 20 nTPM
white matter: 19 nTPM
pons: 17 nTPM
midbrain: 17 nTPM
cerebellum: 17 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.12
DepMap dependency class: selective

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM104 as an antibody target. Whether an autoantibody or antibody against TMEM104 could matter depends on whether native TMEM104 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM104 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM104 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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