Seroatlas · Human Serome Atlas

TMEM101

Transmembrane protein 101

Also known as: FLJ23987, MGC4251, TM101_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96IK0
Gene: TMEM101
Ensembl: ENSG00000091947
Chromosome: 17
Canonical length: 257 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q96IK0|TMEM101
     1  MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI PVPYLYFDMG
    61  AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYIGGYVH YGDWLKVRMY SRTVAIIGGF
   121  LVLASGAGEL YRRKPRSRSL QSTGQVFLGI YLICVAYSLQ HSKEDRLAYL NHLPGGELMI
   181  QLFFVLYGIL ALAFLSGYYV TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL
   241  GESVGIFGTA VILATDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM101 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

seminal vesicle: 105 nTPM
breast: 100 nTPM
kidney: 91 nTPM
endometrium: 60 nTPM
cervix: 42 nTPM
pancreas: 38 nTPM

Single-cell type

renal collecting duct intercalated cells: 795 nCPM
endometrial luminal cells: 777 nCPM
endometrial glandular cells: 434 nCPM
distal convoluted tubule cells: 254 nCPM
endometrial ciliated cells: 107 nCPM
breast hormone-responsive cells: 101 nCPM

Immune cell

myeloid DC: 45 nTPM
T-reg: 45 nTPM
NK-cell: 44 nTPM
plasmacytoid DC: 44 nTPM
intermediate monocyte: 43 nTPM
naive CD4 T-cell: 43 nTPM

Brain region

basal ganglia: 30 nTPM
medulla oblongata: 26 nTPM
choroid plexus: 25 nTPM
midbrain: 25 nTPM
thalamus: 25 nTPM
spinal cord: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of canonical NF-kappaB signal transduction

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

TMEM101 protein
TMEM101 protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM101 as an antibody target. Whether an autoantibody or antibody against TMEM101 could matter depends on whether native TMEM101 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM101 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM101 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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