Seroatlas · Human Serome Atlas

TMEFF2

Tomoregulin-2

Also known as: CT120.2, HPP1, TEFF2_HUMAN, TENB2, TPEF, TR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UIK5
Gene
TMEFF2
Ensembl
ENSG00000144339
Chromosome
2
Canonical length
374 aa
Protein class
Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q9UIK5|TMEFF2
     1  MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT PTGWNCSGYD
    61  DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV PVCGSNGESY QNECYLRQAA
   121  CKQQSEILVV SEGSCATDAG SGSGDGVHEG SGETSQKETS TCDICQFGAE CDEDAEDVWC
   181  VCNIDCSQTN FNPLCASDGK SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG
   241  HYARTDYAEN ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC
   301  EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRKCPRSNR IHRQKQNTGH
   361  YSSDNTTRAS TRLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEFF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 34 nTPM
  • hypothalamus: 23 nTPM
  • hippocampal formation: 23 nTPM
  • cerebral cortex: 22 nTPM
  • amygdala: 21 nTPM
  • midbrain: 21 nTPM

Single-cell type

  • epicardial cells: 1,669 nCPM
  • oligodendrocytes: 1,439 nCPM
  • cardiomyocytes: 1,039 nCPM
  • prostatic glandular cells: 656 nCPM
  • brain inhibitory neurons: 420 nCPM
  • brain excitatory neurons: 419 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 60 nTPM
  • amygdala: 54 nTPM
  • cerebral cortex: 50 nTPM
  • basal ganglia: 50 nTPM
  • hippocampal formation: 47 nTPM
  • hypothalamus: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
1.6
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEFF2 as an antibody target. Whether an autoantibody or antibody against TMEFF2 could matter depends on whether native TMEFF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEFF2 is annotated as secreted, so native TMEFF2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TMEFF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEFF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...