TMEFF1
Tomoregulin-1
Also known as: C9orf2, CT120.1, H7365, TEFF1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IYR6
- Gene
- TMEFF1
- Ensembl
- ENSG00000241697
- Chromosome
- 9
- Canonical length
- 380 aa
- Protein class
- Predicted membrane proteins, Transporters
OverviewNCBI Gene
Enables receptor ligand inhibitor activity. Involved in host-mediated suppression of symbiont invasion. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
380 residues, UniProt reviewed canonical sequence.
>Q8IYR6|TMEFF1
1 MGAAAAEAPL RLPAAPPLAF CCYTSVLLLF AFSLPGSRAS NQPPGGGGGS GGDCPGGKGK
61 SINCSELNVR ESDVRVCDES SCKYGGVCKE DGDGLKCACQ FQCHTNYIPV CGSNGDTYQN
121 ECFLRRAACK HQKEITVIAR GPCYSDNGSG SGEGEEEGSG AEVHRKHSKC GPCKYKAECD
181 EDAENVGCVC NIDCSGYSFN PVCASDGSSY NNPCFVREAS CIKQEQIDIR HLGHCTDTDD
241 TSLLGKKDDG LQYRPDVKDA SDQREDVYIG NHMPCPENLN GYCIHGKCEF IYSTQKASCR
301 CESGYTGQHC EKTDFSILYV VPSRQKLTHV LIAAIIGAVQ IAIIVAIVMC ITRKCPKNNR
361 GRRQKQNLGH FTSDTSSRMVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEFF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 13 nTPM
- basal ganglia: 7.8 nTPM
- midbrain: 7.8 nTPM
- hippocampal formation: 7.6 nTPM
- hypothalamus: 7.4 nTPM
- cerebral cortex: 6.6 nTPM
Single-cell type
- oligodendrocytes: 309 nCPM
- brain inhibitory neurons: 106 nCPM
- other brain neurons: 89 nCPM
- brain excitatory neurons: 71 nCPM
- oligodendrocyte progenitor cells: 52 nCPM
- astrocytes: 27 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 75 nTPM
- basal ganglia: 50 nTPM
- medulla oblongata: 46 nTPM
- thalamus: 46 nTPM
- midbrain: 45 nTPM
- pons: 45 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.47
- gnomAD pLI
- 0.54
- gnomAD missense Z
- 1.1
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TMEFF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEFF1 as an antibody target. Whether an autoantibody or antibody against TMEFF1 could matter depends on whether native TMEFF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEFF1 is annotated at the cell surface, where native TMEFF1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TMEFF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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