Seroatlas · Human Serome Atlas

TMED6

Transmembrane emp24 domain-containing protein 6

Also known as: MGC23911, p24g5, p24gamma5, TMED6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WW62
Gene: TMED6
Ensembl: ENSG00000157315
Chromosome: 16
Canonical length: 240 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q8WW62|TMED6
     1  MSPLLFGAGL VVLNLVTSAR SQKTEPLSGS GDQPLFRGAD RYDFAIMIPP GGTECFWQFA
    61  HQTGYFYFSY EVQRTVGMSH DRHVAATAHN PQGFLIDTSQ GVRGQINFST QETGFYQLCL
   121  SNQHNHFGSV QVYLNFGVFY EGPETDHKQK ERKQLNDTLD AIEDGTQKVQ NNIFHMWRYY
   181  NFARMRKMAD FFLIQSNYNY VNWWSTAQSL VIILSGILQL YFLKRLFNVP TTTDTKKPRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMED6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 282 nTPM

Expression across tissuesHPA

Tissue

pancreas: 282 nTPM
stomach: 60 nTPM
fallopian tube: 21 nTPM
epididymis: 17 nTPM
kidney: 15 nTPM
duodenum: 12 nTPM

Single-cell type

gastric chief cells: 237 nCPM
parietal cells: 90 nCPM
fallopian tube ciliated cells: 10 nCPM
endometrial ciliated cells: 7.9 nCPM
mucous neck cells: 6.3 nCPM
neuroendocrine cells: 5.1 nCPM

Immune cell

memory CD4 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM

Brain region

cerebellum: 3.7 nTPM
cerebral cortex: 3.2 nTPM
white matter: 2.8 nTPM
hippocampal formation: 2.7 nTPM
basal ganglia: 2.5 nTPM
thalamus: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -0.52
DepMap mean gene effect: -0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMED6 as an antibody target. Whether an autoantibody or antibody against TMED6 could matter depends on whether native TMED6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMED6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMED6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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