Seroatlas · Human Serome Atlas

TMCO5B

Transmembrane and coiled-coil domain-containing protein 5B

Also known as: TMC5B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MYB1
Gene: TMCO5B
Canonical length: 307 aa

OverviewNCBI Gene

No narrative summary is available for TMCO5B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>A8MYB1|TMCO5B
     1  MEDVGQNPLD DVKNIFFASS LEAVKQNLDC LNSDLEKDLQ KLDMENQVLL RKIKEKEETI
    61  SSLERKLALS LEEAKEEEEL NYVIDEQEES LRELELETAK LEKSNAILSR NVVEVQKKIS
   121  GLFTNIGLEE ETTKQILEEM KARLQKSTES CAKQEEELAK IESDYQSVSD LCKDQVYYIK
   181  KYQEVLRKMK EEKETLLLEK QISKAQDDSS QTVKPGSILA DTTQRNMERT TIKKQERRCW
   241  YKYFQYLTFM VLVFIRLLAY VIFHLQYINP DLLVDVLPLV LSRGTLESLR KVSHPFLTLA
   301  VEEALPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMCO5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMCO5B as an antibody target. Whether an autoantibody or antibody against TMCO5B could matter depends on whether native TMCO5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMCO5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMCO5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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