Seroatlas · Human Serome Atlas

TMCO5A

Transmembrane and coiled-coil domain-containing protein 5A

Also known as: MGC35118, TMC5A_HUMAN, TMCO5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6Q1
Gene: TMCO5A
Ensembl: ENSG00000166069
Chromosome: 15
Canonical length: 288 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q8N6Q1|TMCO5A
     1  MEISRLAQSK RNIISLNMDL ERDTQRIDEA NQKLLLKIQE REDKIQRLES EIIQTRGLVE
    61  DEEWEKENRT TMERERALQE LEEETARLER KNKTLVHSIT ELQQKLTRKS QKITNCEQSS
   121  PDGALEETKV KLQQLEASYA CQEKELLKVM KEYAFVTQLC EDQALYIKKY QETLKKIEEE
   181  LEALFLEREV SKLVSMNPVE KEHTSQNNEG TPTQKTARLF SKKIFCCLFF ITLFFIRLLS
   241  YMFFHVRFIN PDLLVNVLPK VLGRSTLWKL RCFFFPSLTL ETEDMLPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMCO5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 113 nTPM

Expression across tissuesHPA

Tissue

testis: 113 nTPM
stomach: 0.6 nTPM
fallopian tube: 0.3 nTPM
gallbladder: 0.2 nTPM
salivary gland: 0.2 nTPM
choroid plexus: 0.1 nTPM

Single-cell type

late spermatids: 6,178 nCPM
early spermatids: 1,315 nCPM
late primary spermatocytes: 555 nCPM
sertoli cells: 9.3 nCPM
leydig cells: 5.7 nCPM
respiratory ciliated cells: 4.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 1.2 nTPM
cerebellum: 1.1 nTPM
cerebral cortex: 1.1 nTPM
midbrain: 1.1 nTPM
pons: 1.1 nTPM
thalamus: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMCO5A as an antibody target. Whether an autoantibody or antibody against TMCO5A could matter depends on whether native TMCO5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMCO5A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMCO5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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