Seroatlas · Human Serome Atlas

TMCO4

Transmembrane and coiled-coil domain-containing protein 4

Also known as: DKFZp686C23231, TMCO4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TGY1
Gene: TMCO4
Ensembl: ENSG00000162542
Chromosome: 1
Canonical length: 634 aa
Protein class: Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

634 residues, UniProt reviewed canonical sequence.

>Q5TGY1|TMCO4
     1  MAMWNRPCQR LPQQPLVAEP TAEGEPHLPT GRELTEANRF AYAALCGISL SQLFPEPEHS
    61  SFCTEFMAGL VQWLELSEAV LPTMTAFASG LGGEGADVFV QILLKDPILK DDPTVITQDL
   121  LSFSLKDGHY DARARVLVCH MTSLLQVPLE ELDVLEEMFL ESLKEIKEEE SEMAEASRKK
   181  KENRRKWKRY LLIGLATVGG GTVIGVTGGL AAPLVAAGAA TIIGSAGAAA LGSAAGIAIM
   241  TSLFGAAGAG LTGYKMKKRV GAIEEFTFLP LTEGRQLHIT IAVTGWLASG KYRTFSAPWA
   301  ALAHSREQYC LAWEAKYLME LGNALETILS GLANMVAQEA LKYTVLSGIV AALTWPASLL
   361  SVANVIDNPW GVCLHRSAEV GKHLAHILLS RQQGRRPVTL IGFSLGARVI YFCLQEMAQE
   421  KDCQGIIEDV ILLGAPVEGE AKHWEPFRKV VSGRIINGYC RGDWLLSFVY RTSSVQLRVA
   481  GLQPVLLQDR RVENVDLTSV VSGHLDYAKQ MDAILKAVGI RTKPGWDEKG LLLAPGCLPS
   541  EEPRQAAAAA SSGETPHQVG QTQGPISGDT SKLAMSTDPS QAQVPVGLDQ SEGASLPAAA
   601  SPERPPICSH GMDPNPLGCP DCACKTQGPS TGLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMCO4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 33 nTPM
epididymis: 20 nTPM
duodenum: 16 nTPM
salivary gland: 16 nTPM
prostate: 12 nTPM
stomach: 11 nTPM

Single-cell type

renal collecting duct intercalated cells: 234 nCPM
choroid plexus epithelial cells: 139 nCPM
tuft cells: 127 nCPM
esophageal apical cells: 125 nCPM
epididymal principal cells: 121 nCPM
salivary ionocytes: 115 nCPM

Immune cell

myeloid DC: 7.4 nTPM
intermediate monocyte: 6.7 nTPM
memory CD4 T-cell: 5 nTPM
memory CD8 T-cell: 5 nTPM
naive B-cell: 5 nTPM
gdT-cell: 4.7 nTPM

Brain region

choroid plexus: 13 nTPM
basal ganglia: 4.5 nTPM
midbrain: 4.2 nTPM
thalamus: 3.7 nTPM
medulla oblongata: 3.6 nTPM
hypothalamus: 3.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMCO4.

Disease | ImmuneIEDB

Conditions an epitope on TMCO4 was assayed in.

autoimmune thrombocytopenic purpura B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Alpha/Beta hydrolase fold
Protein of unknown function DUF726
Protein of unknown function (DUF726)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMCO4 as an antibody target. Whether an autoantibody or antibody against TMCO4 could matter depends on whether native TMCO4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMCO4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMCO4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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