Seroatlas · Human Serome Atlas

TMCO3

Transmembrane and coiled-coil domain-containing protein 3

Also known as: C13orf11, FLJ20623, TMCO3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UWJ1
Gene
TMCO3
Ensembl
ENSG00000150403
Chromosome
13
Canonical length
677 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the monovalent cation:proton antiporter 2 (CPA2) family of transporter proteins. Members of this family typically couple the export of monovalent cations, such as potassium or sodium, to the import of protons across cellular membranes. Mutations in this gene have been identified in patients with a rare inherited vision defect, cornea guttata with anterior polar cataract. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

677 residues, UniProt reviewed canonical sequence.

>Q6UWJ1|TMCO3
     1  MKVLGRSFFW VLFPVLPWAV QAVEHEEVAQ RVIKLHRGRG VAAMQSRQWV RDSCRKLSGL
    61  LRQKNAVLNK LKTAIGAVEK DVGLSDEEKL FQVHTFEIFQ KELNESENSV FQAVYGLQRA
   121  LQGDYKDVVN MKESSRQRLE ALREAAIKEE TEYMELLAAE KHQVEALKNM QHQNQSLSML
   181  DEILEDVRKA ADRLEEEIEE HAFDDNKSVK GVNFEAVLRV EEEEANSKQN ITKREVEDDL
   241  GLSMLIDSQN NQYILTKPRD STIPRADHHF IKDIVTIGML SLPCGWLCTA IGLPTMFGYI
   301  ICGVLLGPSG LNSIKSIVQV ETLGEFGVFF TLFLVGLEFS PEKLRKVWKI SLQGPCYMTL
   361  LMIAFGLLWG HLLRIKPTQS VFISTCLSLS STPLVSRFLM GSARGDKEGD IDYSTVLLGM
   421  LVTQDVQLGL FMAVMPTLIQ AGASASSSIV VEVLRILVLI GQILFSLAAV FLLCLVIKKY
   481  LIGPYYRKLH MESKGNKEIL ILGISAFIFL MLTVTELLDV SMELGCFLAG ALVSSQGPVV
   541  TEEIATSIEP IRDFLAIVFF ASIGLHVFPT FVAYELTVLV FLTLSVVVMK FLLAALVLSL
   601  ILPRSSQYIK WIVSAGLAQV SEFSFVLGSR ARRAGVISRE VYLLILSVTT LSLLLAPVLW
   661  RAAITRCVPR PERRSSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMCO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 72 nTPM
  • choroid plexus: 52 nTPM
  • blood vessel: 51 nTPM
  • stomach: 42 nTPM
  • pancreas: 39 nTPM
  • salivary gland: 37 nTPM

Single-cell type

  • neutrophils: 310 nCPM
  • podocytes: 130 nCPM
  • goblet cells: 125 nCPM
  • foveolar cells: 124 nCPM
  • gonadotrophs: 97 nCPM
  • neutrophil progenitors: 97 nCPM

Immune cell

  • neutrophil: 20 nTPM
  • non-classical monocyte: 11 nTPM
  • eosinophil: 8.6 nTPM
  • classical monocyte: 8.3 nTPM
  • myeloid DC: 6.1 nTPM
  • intermediate monocyte: 5.5 nTPM

Brain region

  • choroid plexus: 115 nTPM
  • cerebellum: 73 nTPM
  • cerebral cortex: 57 nTPM
  • white matter: 55 nTPM
  • amygdala: 54 nTPM
  • spinal cord: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.31
DepMap mean gene effect
-0.05
DepMap dependency class
selective

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMCO3 as an antibody target. Whether an autoantibody or antibody against TMCO3 could matter depends on whether native TMCO3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMCO3 is annotated at the cell surface, where native TMCO3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMCO3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMCO3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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