Seroatlas · Human Serome Atlas

TMCO2

Transmembrane and coiled-coil domain-containing protein 2

Also known as: dJ39G22.2, TMCO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z6W1
Gene
TMCO2
Ensembl
ENSG00000188800
Chromosome
1
Canonical length
182 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q7Z6W1|TMCO2
     1  MSTSSSSSWD NLLESLSLST VWNWIQASFL GETSAPQQTS LGLLDNLAPA VQIILRISFL
    61  ILLGIGIYAL WKRSIQSIQK TLLFVITLYK LYKKGSHIFE ALLANPEGSG LRIQDNNNLF
   121  LSLGLQEKIL KKLKTVENKM KNLEGIIVAQ KPATKRDCSS EPYCSCSDCQ SPLSTSGFTS
   181  PI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMCO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
124 nTPM

Expression across tissuesHPA

Tissue

  • testis: 124 nTPM
  • breast: 0.1 nTPM
  • prostate: 0.1 nTPM
  • urinary bladder: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • early spermatids: 3,035 nCPM
  • late spermatids: 1,497 nCPM
  • late primary spermatocytes: 960 nCPM
  • sertoli cells: 8.5 nCPM
  • leydig cells: 4.7 nCPM
  • retinal ganglion cells: 3.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.5 nTPM
  • white matter: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0
gnomAD missense Z
0.41
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane and coiled-coil domain-containing protein 2
  • Transmembrane and coiled-coil domain-containing protein 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMCO2 as an antibody target. Whether an autoantibody or antibody against TMCO2 could matter depends on whether native TMCO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMCO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMCO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMCO2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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