Seroatlas · Human Serome Atlas

TMC7

Transmembrane channel-like protein 7

Also known as: FLJ21240, TMC7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z402
Gene
TMC7
Ensembl
ENSG00000170537
Chromosome
16
Canonical length
723 aa
Protein class
Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to enable ion channel inhibitor activity and mechanosensitive monoatomic ion channel activity. Predicted to be involved in sensory perception of mechanical stimulus. Predicted to be located in plasma membrane. Predicted to be active in neuronal cell body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

723 residues, UniProt reviewed canonical sequence.

>Q7Z402|TMC7
     1  MSESSGSALQ PGRPSRQPAV HPENLSLDSS CFSSPPVNFL QELPSYRSIA RRRTTVHSRD
    61  KQSGTLLKPT DSYSSQLEDR IAENLSSHSL RNYALNISEK RRLRDIQETQ MKYLSEWDQW
   121  KRYSSKSWKR FLEKAREMTT HLELWREDIR SIEGKFGTGI QSYFSFLRFL VLLNLVIFLI
   181  IFMLVLLPVL LTKYKITNSS FVLIPFKDMD KQCTVYPVSS SGLIYFYSYI IDLLSGTGFL
   241  EETSLFYGHY TIDGVKFQNF TYDLPLAYLL STIASLALSL LWIVKRSVEG FKINLIRSEE
   301  HFQSYCNKIF AGWDFCITNR SMADLKHSSL RYELRADLEE ERMRQKIAER TSEETIRIYS
   361  LRLFLNCIVL AVLGACFYAI YVATVFSQEH MKKEIDKMVF GENLFILYLP SIVITLANFI
   421  TPMIFAKIIR YEDYSPGFEI RLTILRCVFM RLATICVLVF TLGSKITSCD DDTCDLCGYN
   481  QKLYPCWETQ VGQEMYKLMI FDFIIILAVT LFVDFPRKLL VTYCSSCKLI QCWGQQEFAI
   541  PDNVLGIVYG QTICWIGAFF SPLLPAIATL KFIIIFYVKE WSLLYTCRPS PRPFRASNSN
   601  FFFLLVLLIG LCLAIIPLTI SISRIPSSKA CGPFTNFNTT WEVIPKTVST FPSSLQSFIH
   661  GVTSEAFAVP FFMIICLIMF YFIALAGAHK RVVIQLREQL SLESRDKCYL IQKLTEAQRD
   721  MRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 12 nTPM
  • testis: 9 nTPM
  • midbrain: 7.7 nTPM
  • urinary bladder: 7.6 nTPM
  • hippocampal formation: 7.2 nTPM
  • basal ganglia: 6 nTPM

Single-cell type

  • urothelial cells: 237 nCPM
  • early spermatids: 234 nCPM
  • prostatic hillock cells: 157 nCPM
  • oligodendrocytes: 136 nCPM
  • late primary spermatocytes: 128 nCPM
  • papillary tip epithelial cells: 92 nCPM

Immune cell

  • basophil: 0.7 nTPM
  • neutrophil: 0.5 nTPM
  • NK-cell: 0.3 nTPM
  • naive B-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • white matter: 52 nTPM
  • basal ganglia: 36 nTPM
  • thalamus: 35 nTPM
  • medulla oblongata: 33 nTPM
  • midbrain: 31 nTPM
  • cerebral cortex: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
1.26
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMC7 as an antibody target. Whether an autoantibody or antibody against TMC7 could matter depends on whether native TMC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMC7 is annotated at the cell surface, where native TMC7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMC7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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