Seroatlas · Human Serome Atlas

TMC5

Transmembrane channel-like protein 5

Also known as: FLJ13593, TMC5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXY8
Gene: TMC5
Ensembl: ENSG00000103534
Chromosome: 16
Canonical length: 1006 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1006 residues, UniProt reviewed canonical sequence.

>Q6UXY8|TMC5
     1  MSAYYRNNWS EEDPDYPDYS GSQNRTQGYL KTQGYPDVPG PLNNPDYPGT RSNPYSVASR
    61  TRPDYPGSLA EPNYPRSLSN PDYSGTRSNA YSAASRTSPD HPTSLPEPDY SEFQSHPYHR
   121  ASSRQPDYPG SQRNPDFAGS SSSGNYAGSR THPDHFGSLE PDYPGAQSNS DHPGPRANLN
   181  HPGSRKNLEH TSFRINPYAD SLGKPDYPGA DIQPNSPPFF GEPDYPSAED NQNLPSTWRE
   241  PDYSDAENGH DYGSSETPKM TRGVLSRTSS IQPSFRHRSD DPVGSLWGEN DYPEGIEMAS
   301  MEMANSYGHS LPGAPGSGYV NPAYVGESGP VHAYGNPPLS ECDWHKSPQG QKLIASLIPM
   361  TSRDRIKAIR NQPRTMEEKR NLRKIVDKEK SKQTHRILQL NCCIQCLNSI SRAYRRSKNS
   421  LSEILNSISL WQKTLKIIGG KFGTSVLSYF NFLRWLLKFN IFSFILNFSF IIIPQFTVAK
   481  KNTLQFTGLE FFTGVGYFRD TVMYYGFYTN STIQHGNSGA SYNMQLAYIF TIGACLTTCF
   541  FSLLFSMAKY FRNNFINPHI YSGGITKLIF CWDFTVTHEK AVKLKQKNLS TEIRENLSEL
   601  RQENSKLTFN QLLTRFSAYM VAWVVSTGVA IACCAAVYYL AEYNLEFLKT HSNPGAVLLL
   661  PFVVSCINLA VPCIYSMFRL VERYEMPRHE VYVLLIRNIF LKISIIGILC YYWLNTVALS
   721  GEECWETLIG QDIYRLLLMD FVFSLVNSFL GEFLRRIIGM QLITSLGLQE FDIARNVLEL
   781  IYAQTLVWIG IFFCPLLPFI QMIMLFIMFY SKNISLMMNF QPPSKAWRAS QMMTFFIFLL
   841  FFPSFTGVLC TLAITIWRLK PSADCGPFRG LPLFIHSIYS WIDTLSTRPG YLWVVWIYRN
   901  LIGSVHFFFI LTLIVLIITY LYWQITEGRK IMIRLLHEQI INEGKDKMFL IEKLIKLQDM
   961  EKKANPSSLV LERREVEQQG FLHLGEHDGS LDLRSRRSVQ EGNPRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

small intestine: 50 nTPM
stomach: 44 nTPM
duodenum: 43 nTPM
gallbladder: 24 nTPM
salivary gland: 22 nTPM
rectum: 21 nTPM

Single-cell type

respiratory ciliated cells: 976 nCPM
enterocytes: 863 nCPM
respiratory deuterosomal cells: 508 nCPM
foveolar cells: 483 nCPM
conjunctival goblet cells: 458 nCPM
mucous neck cells: 424 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 13 nTPM
cerebellum: 2.3 nTPM
basal ganglia: 2.1 nTPM
hippocampal formation: 2 nTPM
cerebral cortex: 1.9 nTPM
amygdala: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

mechanosensitive monoatomic ion channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMC5 as an antibody target. Whether an autoantibody or antibody against TMC5 could matter depends on whether native TMC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMC5 is annotated at the cell surface, where native TMC5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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