Seroatlas · Human Serome Atlas

TMC4

Voltage-gated chloride channel TMC4

Also known as: TMC4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z404
Gene: TMC4
Canonical length: 712 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for TMC4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

712 residues, UniProt reviewed canonical sequence.

>Q7Z404|TMC4
     1  MEENPTLESE AWGSSRGWLA PREARGAPCS SPGPSLSSVL NELPSAATLR YRDPGVLPWG
    61  ALEEEEEDGG RSRKAFTEVT QTELQDPHPS RELPWPMQAR RAHRQRNASR DQVVYGSGTK
   121  TDRWARLLRR SKEKTKEGLR SLQPWAWTLK RIGGQFGAGT ESYFSLLRFL LLLNVLASVL
   181  MACMTLLPTW LGGAPPGPPG PDISSPCGSY NPHSQGLVTF ATQLFNLLSG EGYLEWSPLF
   241  YGFYPPRPRL AVTYLCWAFA VGLICLLLIL HRSVSGLKQT LLAESEALTS YSHRVFSAWD
   301  FGLCGDVHVR LRQRIILYEL KVELEETVVR RQAAVRTLGQ QARVWLVRVL LNLLVVALLG
   361  AAFYGVYWAT GCTVELQEMP LVQELPLLKL GVNYLPSIFI AGVNFVLPPV FKLIAPLEGY
   421  TRSRQIVFIL LRTVFLRLAS LVVLLFSLWN QITCGGDSEA EDCKTCGYNY KQLPCWETVL
   481  GQEMYKLLLF DLLTVLAVAL LIQFPRKLLC GLCPGALGRL AGTQEFQVPD EVLGLIYAQT
   541  VVWVGSFFCP LLPLLNTVKF LLLFYLKKLT LFSTCSPAAR TFRASAANFF FPLVLLLGLA
   601  ISSVPLLYSI FLIPPSKLCG PFRGQSSIWA QIPESISSLP ETTQNFLFFL GTQAFAVPLL
   661  LISSILMAYT VALANSYGRL ISELKRQRQT EAQNKVFLAR RAVALTSTKP AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

pancreas: 43 nTPM
salivary gland: 41 nTPM
colon: 36 nTPM
small intestine: 36 nTPM
duodenum: 31 nTPM
stomach: 31 nTPM

Single-cell type

papillary tip epithelial cells: 67 nCPM
enterocytes: 63 nCPM
renal collecting duct principal cells: 61 nCPM
parietal cells: 60 nCPM
renal connecting tubule cells: 56 nCPM
colonocytes: 52 nCPM

Immune cell

intermediate monocyte: 0.5 nTPM
classical monocyte: 0.3 nTPM
neutrophil: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

midbrain: 1.8 nTPM
medulla oblongata: 1.6 nTPM
cerebral cortex: 1.1 nTPM
pons: 1 nTPM
hippocampal formation: 0.7 nTPM
amygdala: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 1.07
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMC4 as an antibody target. Whether an autoantibody or antibody against TMC4 could matter depends on whether native TMC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMC4 is annotated at the cell surface, where native TMC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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