Seroatlas · Human Serome Atlas

TMC3

Transmembrane channel-like protein 3

Also known as: TMC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5M5
Gene: TMC3
Ensembl: ENSG00000188869
Chromosome: 15
Canonical length: 1100 aa
Protein class: Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1100 residues, UniProt reviewed canonical sequence.

>Q7Z5M5|TMC3
     1  MKTSKASQRY RGIRRNASQC YLYQESLLLS NLDDSFSADE TGDSNDPEQI FQNIQFQKDL
    61  MANIRCRPWT MGQKLRALRQ AKNIVLKFEG RLTRTRGYQA AGAELWRKFA RLACNFVVIF
   121  IPWEMRIKKI ESHFGSGVAS YFIFLRWLFG INIVLTIMTG AFIVIPELIA GQPFGSTARK
   181  TIPKEQVSSA QDLDTVWSLG GYLQYSVLFY GYYGRERKIG RAGYRLPLAY FLVGMAVFAY
   241  SFIILLKKMA KNSRTSLASA SNENYTFCWR VFCAWDYLIG NPEAAESKTA AIVNSIREAI
   301  LEEQEKKKSK NLAVTICLRI IANILVLLSL AGSIYLIYFV VDRSQKLEQS KKELTLWEKN
   361  EVSVVVSLVT MIAPSAFDLI AALEMYHPRT TLRFQLARVL VLYLGNLYSL IIALLDKVNS
   421  MSIEEMATKN NTSHWIDSTT FFATRTAPEE EKWSTSRPGM GLRRNNTWAL EETSISAYTM
   481  PLIKANKTSL HTQSPQDQCW ETYVGQEMLK LSIIDMLFTV ASILLIDFFR GLFVRYLSDY
   541  WCWDLESKFP EYGEFKIAEN VLHLVYNQGM IWMGAFFSPC LPAFNVLKLI GLMYLRSWAV
   601  LTCNVPHQQV FRASRSNNFY LAMLLFMLFL CMLPTIFAIV RYKPSLNCGP FSGQEKIYDI
   661  VSETIEKDFP VWFGSVVGHI SSPVVILPAV LLLFMLIYYL QSIARSLKLS NHQLKMQIQN
   721  ARSEDKKKVA QMVEARIQTQ EESTKKLPND SDLTSQLSSA HSGTPQNNGN VAHFDSGSSK
   781  SGRIETVAQS MPQSPRPGDR APSSPLPGVP KSRLEHETNR YLHGLCASTS DLHRNRSRTP
   841  MTFTTHIEDV HSEPLFRKDF QQINPPHRGP QASTLLAQGP RPHAPRYYVI NECDSYKKKH
   901  LNVWPERHFK IDASGDIVEL YPRNVRQYAS RVPRQPPSPQ LSEEEEETPS RDWIKRSLPP
   961  RSLIDLRRAP HFYIGERSES QTRDPEHQGR VHYKSWNEDF EGHLERPAYV PRKPRSRNFQ
  1021  YPQPPLKPRG KPRFEPSLTE SDSVSAASSS DQQNSSADQY LQVTHSQGRF PRSVGQPSRR
  1081  KAKSGQELTV DLDDLICSDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 79 nTPM
epididymis: 1.5 nTPM
fallopian tube: 0.8 nTPM
thyroid gland: 0.8 nTPM
bone marrow: 0.7 nTPM
cerebral cortex: 0.7 nTPM

Single-cell type

epicardial cells: 34 nCPM
retinal ganglion cells: 7.7 nCPM
medullary thymic epithelial cells: 4.8 nCPM
paneth cells: 3.9 nCPM
mesothelial cells: 3.6 nCPM
neutrophil progenitors: 3.5 nCPM

Immune cell

naive B-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
T-reg: 0.2 nTPM
gdT-cell: 0.1 nTPM

Brain region

pons: 8.1 nTPM
cerebellum: 6.7 nTPM
cerebral cortex: 3.9 nTPM
medulla oblongata: 3.9 nTPM
white matter: 3.7 nTPM
basal ganglia: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

mechanosensitive monoatomic ion channel activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMC3 as an antibody target. Whether an autoantibody or antibody against TMC3 could matter depends on whether native TMC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMC3 is annotated at the cell surface, where native TMC3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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