TMA7
Translation machinery-associated protein 7
Also known as: CCDC72, HSPC016, TMA7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y2S6
- Gene
- TMA7
- Ensembl
- ENSG00000232112
- Chromosome
- 3
- Canonical length
- 64 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Nucleoli rim,Nuclear bodies
OverviewNCBI Gene
No narrative summary is available for TMA7 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
64 residues, UniProt reviewed canonical sequence.
>Q9Y2S6|TMA7
1 MSGREGGKKK PLKQPKKQAK EMDEEDKAFK QKQKEEQKKL EELKAKAAGK GPLATGGIKK
61 SGKKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 531 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 531 nTPM
- amygdala: 513 nTPM
- cerebral cortex: 484 nTPM
- skeletal muscle: 467 nTPM
- basal ganglia: 465 nTPM
- midbrain: 456 nTPM
Single-cell type
- late spermatids: 1,589 nCPM
- parietal cells: 1,430 nCPM
- megakaryocytes: 1,150 nCPM
- hepatocytes: 1,112 nCPM
- esophageal suprabasal cells: 1,022 nCPM
- enterocytes: 1,011 nCPM
Immune cell
- total PBMC: 2,651 nTPM
- eosinophil: 2,177 nTPM
- neutrophil: 2,033 nTPM
- basophil: 1,896 nTPM
- T-reg: 1,642 nTPM
- plasmacytoid DC: 1,512 nTPM
Brain region
- cerebral cortex: 167 nTPM
- white matter: 164 nTPM
- hypothalamus: 163 nTPM
- medulla oblongata: 160 nTPM
- spinal cord: 157 nTPM
- pons: 154 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.75
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.1
- DepMap mean gene effect
- -0.14
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMA7 as an antibody target. Whether an autoantibody or antibody against TMA7 could matter depends on whether native TMA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMA7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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