Seroatlas · Human Serome Atlas

TM9SF1

Transmembrane 9 superfamily member 1

Also known as: HMP70, MP70, TM9S1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15321
Gene: TM9SF1
Ensembl: ENSG00000100926
Chromosome: 14
Canonical length: 606 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in protein localization to membrane. Predicted to be located in autophagosome membrane; cytoplasmic vesicle; and lysosomal membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

606 residues, UniProt reviewed canonical sequence.

>O15321|TM9SF1
     1  MTVVGNPRSW SCQWLPILIL LLGTGHGPGV EGVTHYKAGD PVILYVNKVG PYHNPQETYH
    61  YYQLPVCCPE KIRHKSLSLG EVLDGDRMAE SLYEIRFREN VEKRILCHMQ LSSAQVEQLR
   121  QAIEELYYFE FVVDDLPIRG FVGYMEESGF LPHSHKIGLW THLDFHLEFH GDRIIFANVS
   181  VRDVKPHSLD GLRPDEFLGL THTYSVRWSE TSVERRSDRR RGDDGGFFPR TLEIHWLSII
   241  NSMVLVFLLV GFVAVILMRV LRNDLARYNL DEETTSAGSG DDFDQGDNGW KIIHTDVFRF
   301  PPYRGLLCAV LGVGAQFLAL GTGIIVMALL GMFNVHRHGA INSAAILLYA LTCCISGYVS
   361  SHFYRQIGGE RWVWNIILTT SLFSVPFFLT WSVVNSVHWA NGSTQALPAT TILLLLTVWL
   421  LVGFPLTVIG GIFGKNNASP FDAPCRTKNI AREIPPQPWY KSTVIHMTVG GFLPFSAISV
   481  ELYYIFATVW GREQYTLYGI LFFVFAILLS VGACISIALT YFQLSGEDYR WWWRSVLSVG
   541  STGLFIFLYS VFYYARRSNM SGAVQTVEFF GYSLLTGYVF FLMLGTISFF SSLKFIRYIY
   601  VNLKMD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TM9SF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

pancreas: 54 nTPM
salivary gland: 40 nTPM
adrenal gland: 40 nTPM
liver: 37 nTPM
choroid plexus: 35 nTPM
parathyroid gland: 34 nTPM

Single-cell type

ependymal cells: 25 nCPM
bergmann glia: 16 nCPM
astrocytes: 13 nCPM
oligodendrocyte progenitor cells: 12 nCPM
oligodendrocytes: 12 nCPM
other brain neurons: 10 nCPM

Immune cell

plasmacytoid DC: 39 nTPM
basophil: 33 nTPM
neutrophil: 28 nTPM
eosinophil: 25 nTPM
myeloid DC: 23 nTPM
NK-cell: 23 nTPM

Brain region

choroid plexus: 31 nTPM
midbrain: 12 nTPM
medulla oblongata: 11 nTPM
spinal cord: 10 nTPM
thalamus: 10 nTPM
white matter: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 2.11
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TM9SF1 as an antibody target. Whether an autoantibody or antibody against TM9SF1 could matter depends on whether native TM9SF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TM9SF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TM9SF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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