Seroatlas · Human Serome Atlas

TM7SF3

Transmembrane 7 superfamily member 3

Also known as: TM7S3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NS93
Gene: TM7SF3
Ensembl: ENSG00000064115
Chromosome: 12
Canonical length: 570 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in cellular response to unfolded protein; negative regulation of programmed cell death; and positive regulation of insulin secretion. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q9NS93|TM7SF3
     1  MGFLQLLVVA VLASEHRVAG AAEVFGNSSE GLIEFSVGKF RYFELNRPFP EEAILHDISS
    61  NVTFLIFQIH SQYQNTTVSF SPTLLSNSSE TGTASGLVFI LRPEQSTCTW YLGTSGIQPV
   121  QNMAILLSYS ERDPVPGGCN LEFDLDIDPN IYLEYNFFET TIKFAPANLG YARGVDPPPC
   181  DAGTDQDSRW RLQYDVYQYF LPENDLTEEM LLKHLQRMVS VPQVKASALK VVTLTANDKT
   241  SVSFSSLPGQ GVIYNVIVWD PFLNTSAAYI PAHTYACSFE AGEGSCASLG RVSSKVFFTL
   301  FALLGFFICF FGHRFWKTEL FFIGFIIMGF FFYILITRLT PIKYDVNLIL TAVTGSVGGM
   361  FLVAVWWRFG ILSICMLCVG LVLGFLISSV TFFTPLGNLK IFHDDGVFWV TFSCIAILIP
   421  VVFMGCLRIL NILTCGVIGS YSVVLAIDSY WSTSLSYITL NVLKRALNKD FHRAFTNVPF
   481  QTNDFIILAV WGMLAVSGIT LQIRRERGRP FFPPHPYKLW KQERERRVTN ILDPSYHIPP
   541  LRERLYGRLT QIKGLFQKEQ PAGERTPLLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TM7SF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 239 nTPM

Expression across tissuesHPA

Tissue

kidney: 239 nTPM
liver: 129 nTPM
pancreas: 111 nTPM
thymus: 94 nTPM
rectum: 65 nTPM
bone marrow: 62 nTPM

Single-cell type

proximal tubule cells: 349 nCPM
melanocytes: 270 nCPM
cholangiocytes: 264 nCPM
late spermatids: 253 nCPM
megakaryocyte progenitors: 209 nCPM
neutrophil progenitors: 203 nCPM

Immune cell

eosinophil: 19 nTPM
T-reg: 14 nTPM
NK-cell: 14 nTPM
naive B-cell: 13 nTPM
myeloid DC: 12 nTPM
naive CD4 T-cell: 11 nTPM

Brain region

choroid plexus: 85 nTPM
white matter: 74 nTPM
thalamus: 68 nTPM
cerebral cortex: 67 nTPM
spinal cord: 67 nTPM
medulla oblongata: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

TM7S3/TM198-like domain
TM7S3/TM198-like domain
Transmembrane 7 superfamily member 3
TM7SF3-like, N-terminal immunoglobulin-like domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TM7SF3 as an antibody target. Whether an autoantibody or antibody against TM7SF3 could matter depends on whether native TM7SF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TM7SF3 is annotated at the cell surface, where native TM7SF3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TM7SF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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