TM7SF2
Delta(14)-sterol reductase TM7SF2
Also known as: ANG1, DHCR14A, ERG24_HUMAN, NET47
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O76062
- Gene
- TM7SF2
- Ensembl
- ENSG00000149809
- Chromosome
- 11
- Canonical length
- 418 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted membrane proteins
- Subcellular location
- Endoplasmic reticulum,Vesicles
OverviewNCBI Gene
Enables Delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in endoplasmic reticulum. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
418 residues, UniProt reviewed canonical sequence.
>O76062|TM7SF2
1 MAPTQGPRAP LEFGGPLGAA ALLLLLPATM FHLLLAARSG PARLLGPPAS LPGLEVLWSP
61 RALLLWLAWL GLQAALYLLP ARKVAEGQEL KDKSRLRYPI NGFQALVLTA LLVGLGMSAG
121 LPLGALPEML LPLAFVATLT AFIFSLFLYM KAQVAPVSAL APGGNSGNPI YDFFLGRELN
181 PRICFFDFKY FCELRPGLIG WVLINLALLM KEAELRGSPS LAMWLVNGFQ LLYVGDALWH
241 EEAVLTTMDI THDGFGFMLA FGDMAWVPFT YSLQAQFLLH HPQPLGLPMA SVICLINATG
301 YYIFRGANSQ KNTFRKNPSD PRVAGLETIS TATGRKLLVS GWWGMVRHPN YLGDLIMALA
361 WSLPCGVSHL LPYFYLLYFT ALLVHREARD ERQCLQKYGL AWQEYCRRVP YRIMPYIYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TM7SF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 243 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 243 nTPM
- choroid plexus: 101 nTPM
- liver: 94 nTPM
- skin: 69 nTPM
- pancreas: 64 nTPM
- adipose tissue: 60 nTPM
Single-cell type
- esophageal apical cells: 509 nCPM
- breast lactating cells: 265 nCPM
- esophageal suprabasal cells: 198 nCPM
- parietal cells: 193 nCPM
- adrenal cortex cells: 171 nCPM
- müller glia: 167 nCPM
Immune cell
- plasmacytoid DC: 38 nTPM
- NK-cell: 13 nTPM
- memory B-cell: 13 nTPM
- naive B-cell: 12 nTPM
- naive CD4 T-cell: 12 nTPM
- gdT-cell: 9.1 nTPM
Brain region
- choroid plexus: 107 nTPM
- white matter: 43 nTPM
- medulla oblongata: 42 nTPM
- cerebellum: 39 nTPM
- pons: 39 nTPM
- thalamus: 39 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.02
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.4
- DepMap mean gene effect
- -0.21
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TM7SF2 as an antibody target. Whether an autoantibody or antibody against TM7SF2 could matter depends on whether native TM7SF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TM7SF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TM7SF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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