Seroatlas · Human Serome Atlas

TM4SF4

Transmembrane 4 L6 family member 4

Also known as: il-TMP, T4S4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48230
Gene: TM4SF4
Ensembl: ENSG00000169903
Chromosome: 3
Canonical length: 202 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>P48230|TM4SF4
     1  MCTGGCARCL GGTLIPLAFF GFLANILLFF PGGKVIDDND HLSQEIWFFG GILGSGVLMI
    61  FPALVFLGLK NNDCCGCCGN EGCGKRFAMF TSTIFAVVGF LGAGYSFIIS AISINKGPKC
   121  LMANSTWGYP FHDGDYLNDE ALWNKCREPL NVVPWNLTLF SILLVVGGIQ MVLCAIQVVN
   181  GLLGTLCGDC QCCGCCGGDG PV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TM4SF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 888 nTPM

Expression across tissuesHPA

Tissue

gallbladder: 888 nTPM
liver: 658 nTPM
duodenum: 611 nTPM
small intestine: 485 nTPM
pancreas: 68 nTPM
stomach: 20 nTPM

Single-cell type

cholangiocytes: 2,007 nCPM
hepatocytes: 890 nCPM
pancreatic islet cells: 426 nCPM
neuroendocrine cells: 235 nCPM
pancreatic duct cells: 133 nCPM
enterocytes: 116 nCPM

Immune cell

intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

spinal cord: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.18
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tissue regeneration

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TM4SF4 as an antibody target. Whether an autoantibody or antibody against TM4SF4 could matter depends on whether native TM4SF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TM4SF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TM4SF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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