Seroatlas · Human Serome Atlas

TM2D2

TM2 domain-containing protein 2

Also known as: BLP1, TM2D2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BX73
Gene: TM2D2
Ensembl: ENSG00000169490
Chromosome: 8
Canonical length: 214 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q9BX73|TM2D2
     1  MVLGGCPVSY LLLCGQAALL LGNLLLLHCV SRSHSQNATA EPELTSAGAA QPEGPGGAAS
    61  WEYGDPHSPV ILCSYLPDEF IECEDPVDHV GNATASQELG YGCLKFGGQA YSDVEHTSVQ
   121  CHALDGIECA SPRTFLRENK PCIKYTGHYF ITTLLYSFFL GCFGVDRFCL GHTGTAVGKL
   181  LTLGGLGIWW FVDLILLITG GLMPSDGSNW CTVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TM2D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 48 nTPM
placenta: 32 nTPM
kidney: 31 nTPM
liver: 28 nTPM
testis: 26 nTPM
epididymis: 25 nTPM

Single-cell type

hofbauer cells: 425 nCPM
platelets: 182 nCPM
extravillous trophoblasts: 124 nCPM
cytotrophoblasts: 106 nCPM
esophageal apical cells: 103 nCPM
migrating cytotrophoblasts: 93 nCPM

Immune cell

basophil: 65 nTPM
plasmacytoid DC: 61 nTPM
T-reg: 42 nTPM
total PBMC: 35 nTPM
memory CD4 T-cell: 35 nTPM
intermediate monocyte: 34 nTPM

Brain region

choroid plexus: 37 nTPM
white matter: 25 nTPM
hypothalamus: 24 nTPM
thalamus: 23 nTPM
cerebellum: 23 nTPM
pons: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.01
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TM2D2 as an antibody target. Whether an autoantibody or antibody against TM2D2 could matter depends on whether native TM2D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TM2D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TM2D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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