TM2D1

Protein identityUniProt · HPA

UniProt accession

Q9BX74

Gene

TM2D1

Ensembl

ENSG00000162604

Chromosome

1

Canonical length

207 aa

Protein class

Predicted membrane proteins

Subcellular location

Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>Q9BX74|TM2D1
     1  MAAAWPSGPS APEAVTARLV GVLWFVSVTT GPWGAVATSA GGEESLKCED LKVGQYICKD
    61  PKINDATQEP VNCTNYTAHV SCFPAPNITC KDSSGNETHF TGNEVGFFKP ISCRNVNGYS
   121  YKVAVALSLF LGWLGADRFY LGYPALGLLK FCTVGFCGIG SLIDFILISM QIVGPSDGSS
   181  YIIDYYGTRL TRLSITNETF RKTQLYP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TM2D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

2

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

43 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.12

gnomAD pLI

0

gnomAD missense Z

0.13

DepMap mean gene effect

-0.18

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic signaling pathway

Molecular functions

• amyloid-beta binding
• G protein-coupled receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• TM2 domain
• TM2 domain-containing protein 1-3-like
• TM2 domain

KeywordsUniProt

• Apoptosis
• Glycoprotein
• Membrane
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TM2D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APP