Seroatlas · Human Serome Atlas

TLX1NB

Putative TLX1 neighbor protein

Also known as: TLXNB_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CAT3
Gene: TLX1NB
Canonical length: 122 aa

OverviewNCBI Gene

No narrative summary is available for TLX1NB in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>P0CAT3|TLX1NB
     1  MAPLQLLHPW GRRGAWASQH SLLSQEAMGP GEGAEPTPWG YLRAEHWGAS PSGAPTLPFA
    61  PDECSLTPGS PPHPLNKQKH HPPHPSQTQK DLVPRSPQLE KSRIRLRRTL RNLGGGRGQR
   121  GQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLX1NB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.08

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLX1NB as an antibody target. Whether an autoantibody or antibody against TLX1NB could matter depends on whether native TLX1NB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLX1NB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLX1NB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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