TLR1

Protein identityUniProt · HPA

UniProt accession

Q15399

Gene

TLR1

Ensembl

ENSG00000174125

Chromosome

4

Canonical length

786 aa

Protein class

CD markers, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

786 residues, UniProt reviewed canonical sequence.

>Q15399|TLR1
     1  MTSIFHFAII FMLILQIRIQ LSEESEFLVD RSKNGLIHVP KDLSQKTTIL NISQNYISEL
    61  WTSDILSLSK LRILIISHNR IQYLDISVFK FNQELEYLDL SHNKLVKISC HPTVNLKHLD
   121  LSFNAFDALP ICKEFGNMSQ LKFLGLSTTH LEKSSVLPIA HLNISKVLLV LGETYGEKED
   181  PEGLQDFNTE SLHIVFPTNK EFHFILDVSV KTVANLELSN IKCVLEDNKC SYFLSILAKL
   241  QTNPKLSNLT LNNIETTWNS FIRILQLVWH TTVWYFSISN VKLQGQLDFR DFDYSGTSLK
   301  ALSIHQVVSD VFGFPQSYIY EIFSNMNIKN FTVSGTRMVH MLCPSKISPF LHLDFSNNLL
   361  TDTVFENCGH LTELETLILQ MNQLKELSKI AEMTTQMKSL QQLDISQNSV SYDEKKGDCS
   421  WTKSLLSLNM SSNILTDTIF RCLPPRIKVL DLHSNKIKSI PKQVVKLEAL QELNVAFNSL
   481  TDLPGCGSFS SLSVLIIDHN SVSHPSADFF QSCQKMRSIK AGDNPFQCTC ELGEFVKNID
   541  QVSSEVLEGW PDSYKCDYPE SYRGTLLKDF HMSELSCNIT LLIVTIVATM LVLAVTVTSL
   601  CSYLDLPWYL RMVCQWTQTR RRARNIPLEE LQRNLQFHAF ISYSGHDSFW VKNELLPNLE
   661  KEGMQICLHE RNFVPGKSIV ENIITCIEKS YKSIFVLSPN FVQSEWCHYE LYFAHHNLFH
   721  EGSNSLILIL LEPIPQYSIP SSYHKLKSLM ARRTYLEWPK EKSKRGLFWA NLRAAINIKL
   781  TEQAKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

32 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TLR1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 152 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Rheumatoid arthritis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.85

gnomAD pLI

0

gnomAD missense Z

-0.7

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to triacyl bacterial lipopeptide
• detection of triacyl bacterial lipopeptide
• immune response
• inflammatory response
• innate immune response
• macrophage activation
• microglial cell activation
• positive regulation of interleukin-6 production
• positive regulation of interleukin-8 production
• positive regulation of toll-like receptor 2 signaling pathway
• positive regulation of tumor necrosis factor production
• signal transduction
• toll-like receptor signaling pathway

Molecular functions

• identical protein binding
• lipopeptide binding
• signaling receptor activity
• Toll-like receptor 2 binding
• transmembrane signaling receptor activity

Cellular components

• Golgi apparatus
• membrane
• membrane raft
• phagocytic vesicle membrane
• plasma membrane
• receptor complex
• Toll-like receptor 1-Toll-like receptor 2 protein complex

Protein domainsUniProt · Pfam · InterPro

• Toll/interleukin-1 receptor homology (TIR) domain
• Cysteine-rich flanking region, C-terminal
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Toll-like receptor
• Leucine-rich repeat domain superfamily
• Toll/interleukin-1 receptor homology (TIR) domain superfamily
• Leucine rich repeat C-terminal domain
• TIR domain
• Leucine rich repeat

KeywordsUniProt

• Cell membrane
• Cytoplasmic vesicle
• Disulfide bond
• Glycoprotein
• Golgi apparatus
• Immunity
• Inflammatory response
• Innate immunity
• Leucine-rich repeat
• Membrane
• NAD
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TLR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CNPY3
• TLR2