Seroatlas · Human Serome Atlas

TLNRD1

Talin rod domain-containing protein 1

Also known as: MESDC1, MGC99595, TLRN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1K6
Gene: TLNRD1
Ensembl: ENSG00000140406
Chromosome: 15
Canonical length: 362 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytoplasmic bodies
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that is regulated by micro RNA MiR-574-3, and is thought to have an oncogenic function in human bladder cancer. A similar gene in mouse is located in a chromosomal region critical for differentiation of mesoderm, which affects embryo patterning and the formation of heart, muscle, blood, skeleton and the urogenital system. The mouse gene is expressed in early development, and in the adult. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>Q9H1K6|TLNRD1
     1  MASGSAGKPT GEAASPAPAS AIGGASSQPR KRLVSVCDHC KGKMQLVADL LLLSSEARPV
    61  LFEGPASSGA GAESFEQCRD TIIARTKGLS ILTHDVQSQL NMGRFGEAGD SLVELGDLVV
   121  SLTECSAHAA YLAAVATPGA QPAQPGLVDR YRVTRCRHEV EQGCAVLRAT PLADMTPQLL
   181  LEVSQGLSRN LKFLTDACAL ASDKSRDRFS REQFKLGVKC MSTSASALLA CVREVKVAPS
   241  ELARSRCALF SGPLVQAVSA LVGFATEPQF LGRAAAVSAE GKAVQTAILG GAMSVVSACV
   301  LLTQCLRDLA QHPDGGAKMS DHRERLRNSA CAVSEGCTLL SQALRERSSP RTLPPVNSNS
   361  VN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLNRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 14 nTPM
lung: 14 nTPM
adipose tissue: 13 nTPM
basal ganglia: 12 nTPM
spleen: 11 nTPM
adrenal gland: 9.8 nTPM

Single-cell type

esophageal apical cells: 107 nCPM
urothelial cells: 87 nCPM
vascular endothelial cells: 56 nCPM
hofbauer cells: 56 nCPM
epididymal basal cells: 54 nCPM
kupffer cells: 52 nCPM

Immune cell

NK-cell: 1.2 nTPM
memory B-cell: 0.8 nTPM
memory CD4 T-cell: 0.7 nTPM
memory CD8 T-cell: 0.7 nTPM
gdT-cell: 0.6 nTPM
basophil: 0.5 nTPM

Brain region

cerebellum: 33 nTPM
basal ganglia: 26 nTPM
medulla oblongata: 22 nTPM
thalamus: 21 nTPM
choroid plexus: 21 nTPM
cerebral cortex: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.91
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

stress fiber

Protein domainsUniProt · Pfam · InterPro

Talin, IBS2B domain
Talin IBS2B domain
Talin rod domain-containing protein 1

KeywordsUniProt

Acetylation

InteractionsUniProt · HPA

Protein binding partners of TLNRD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CCM2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLNRD1 as an antibody target. Whether an autoantibody or antibody against TLNRD1 could matter depends on whether native TLNRD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLNRD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLNRD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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