Seroatlas · Human Serome Atlas

TLE7

Transducin-like enhancer protein 7

Also known as: TLE7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1W2PR48
Gene
TLE7
Ensembl
ENSG00000260734
Chromosome
16
Canonical length
441 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>A0A1W2PR48|TLE7
     1  MSGEKEEASL RMFGAYGEPE ERRDVLESSG VSSQPEPQVQ QQLGSLLGVP WQPPGPPIQH
    61  SPADQETSTV TQQQWHLQGL GRSELQAAGL PDAQPGEAAE SSPSFLLGSE VGQPYSSSSP
   121  SEEVLSLLRA IPPIPDEVVV RQKRAPQGSW KVGTLFHGKR VYAVAISGST HHVYTCGSGY
   181  IRVWDESALH AGEKAPRAQL DLQHPQDRVV TCKLFPDERS LITGGASQAV TLWDLAPTPQ
   241  VRAQLTSTGP TCYSLAVSSD AHICLACFHG FVEIWDLQNQ ILIRKHEVPV YGSRCVDITG
   301  NIFWTGGEDT ILYSWDLRSY QRLHQHNLQN EILSITHDPG EEWVLAGLRT SDIVFLHTRR
   361  NEQFKALMKK YTRHHSLKFA SCGSYFVTAI DTRLSGLEAP SLQKLFQIEE SSGILCCDVS
   421  SDNQYLVMGS SSSATIYQLL Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLE7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
0.7 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.7 nTPM
  • ovary: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • oocytes: 55 nCPM
  • differentiating spermatogonia: 5 nCPM
  • undifferentiated spermatogonia: 3.1 nCPM
  • early primary spermatocytes: 0.6 nCPM
  • mucous neck cells: 0.4 nCPM
  • extravillous trophoblasts: 0.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLE7 as an antibody target. Whether an autoantibody or antibody against TLE7 could matter depends on whether native TLE7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLE7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLE7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TLE7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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