Seroatlas · Human Serome Atlas

TLDC2

TLD domain-containing protein 2

Also known as: C20orf118, dJ132F21.2, TLDC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0PJX2
Gene: TLDC2
Ensembl: ENSG00000101342
Chromosome: 20
Canonical length: 215 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in response to oxidative stress. Predicted to act upstream of or within negative regulation of cellular response to oxidative stress. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>A0PJX2|TLDC2
     1  MRGLRWRYTR LPSQVEDTLS GEEGNEEEEE EEAAPDPAAA PEDPTVPQLT EASQVLSASE
    61  IRQLSFHFPP RVTGHPWSLV FCTSRDGFSL QSLYRRMEGC SGPVLLVLRD QDGQIFGAFS
   121  SSAIRLSKGF YGTGETFLFS FSPQLKVFKW TGSNSFFVKG DLDSLMMGSG SGRFGLWLDG
   181  DLFRGGSSPC PTFNNEVLAR QEQFCIQELE AWLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

duodenum: 17 nTPM
small intestine: 16 nTPM
rectum: 12 nTPM
colon: 11 nTPM
lung: 9.3 nTPM
adipose tissue: 8.4 nTPM

Single-cell type

enterocytes: 134 nCPM
tuft cells: 69 nCPM
schwann cells: 55 nCPM
colonocytes: 42 nCPM
mast cells: 34 nCPM
renal collecting duct intercalated cells: 32 nCPM

Immune cell

basophil: 4.7 nTPM
myeloid DC: 0.8 nTPM
NK-cell: 0.8 nTPM
non-classical monocyte: 0.7 nTPM
intermediate monocyte: 0.6 nTPM
naive B-cell: 0.6 nTPM

Brain region

choroid plexus: 7.8 nTPM
white matter: 6.6 nTPM
thalamus: 6.4 nTPM
medulla oblongata: 5.4 nTPM
pons: 5.4 nTPM
hypothalamus: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.02
gnomAD missense Z: -0.3
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

response to oxidative stress

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLDC2 as an antibody target. Whether an autoantibody or antibody against TLDC2 could matter depends on whether native TLDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLDC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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