Seroatlas · Human Serome Atlas

TINAGL1

Tubulointerstitial nephritis antigen-like

Also known as: ARG1, LCN7, LIECG3, P3ECSL, TINAGRP, TINAL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZM7
Gene
TINAGL1
Ensembl
ENSG00000142910
Chromosome
1
Canonical length
467 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>Q9GZM7|TINAGL1
     1  MWRCPLGLLL LLPLAGHLAL GAQQGRGRRE LAPGLHLRGI RDAGGRYCQE QDLCCRGRAD
    61  DCALPYLGAI CYCDLFCNRT VSDCCPDFWD FCLGVPPPFP PIQGCMHGGR IYPVLGTYWD
   121  NCNRCTCQEN RQWQCDQEPC LVDPDMIKAI NQGNYGWQAG NHSAFWGMTL DEGIRYRLGT
   181  IRPSSSVMNM HEIYTVLNPG EVLPTAFEAS EKWPNLIHEP LDQGNCAGSW AFSTAAVASD
   241  RVSIHSLGHM TPVLSPQNLL SCDTHQQQGC RGGRLDGAWW FLRRRGVVSD HCYPFSGRER
   301  DEAGPAPPCM MHSRAMGRGK RQATAHCPNS YVNNNDIYQV TPVYRLGSND KEIMKELMEN
   361  GPVQALMEVH EDFFLYKGGI YSHTPVSLGR PERYRRHGTH SVKITGWGEE TLPDGRTLKY
   421  WTAANSWGPA WGERGHFRIV RGVNECDIES FVLGVWGRVG MEDMGHH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TINAGL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
306 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 306 nTPM
  • heart muscle: 222 nTPM
  • kidney: 178 nTPM
  • placenta: 172 nTPM
  • adipose tissue: 162 nTPM
  • breast: 143 nTPM

Single-cell type

  • syncytiotrophoblasts: 2,158 nCPM
  • cytotrophoblasts: 1,417 nCPM
  • migrating cytotrophoblasts: 1,096 nCPM
  • vascular smooth muscle cells: 389 nCPM
  • pericytes: 356 nCPM
  • extravillous trophoblasts: 210 nCPM

Immune cell

  • basophil: 2 nTPM
  • neutrophil: 0.6 nTPM
  • NK-cell: 0.4 nTPM
  • gdT-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM

Brain region

  • thalamus: 28 nTPM
  • pons: 24 nTPM
  • medulla oblongata: 23 nTPM
  • amygdala: 22 nTPM
  • midbrain: 20 nTPM
  • hypothalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
1.27
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TINAGL1 as an antibody target. Whether an autoantibody or antibody against TINAGL1 could matter depends on whether native TINAGL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TINAGL1 is annotated as secreted, so native TINAGL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis.

Canonical record: https://seroatlas.com/gene/TINAGL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...