Seroatlas · Human Serome Atlas

TIMP4

Metalloproteinase inhibitor 4

Also known as: TIMP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99727
Gene: TIMP4
Ensembl: ENSG00000157150
Chromosome: 3
Canonical length: 224 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q99727|TIMP4
     1  MPGSPRPAPS WVLLLRLLAL LRPPGLGEAC SCAPAHPQQH ICHSALVIRA KISSEKVVPA
    61  SADPADTEKM LRYEIKQIKM FKGFEKVKDV QYIYTPFDSS LCGVKLEANS QKQYLLTGQV
   121  LSDGKVFIHL CNYIEPWEDL SLVQRESLNH HYHLNCGCQI TTCYTVPCTI SAPNECLWTD
   181  WLLERKLYGY QAQHYVCMKH VDGTCSWYRG HLPLRKEFVD IVQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIMP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 229 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 229 nTPM
breast: 172 nTPM
cerebellum: 69 nTPM
blood vessel: 65 nTPM
heart muscle: 43 nTPM
thyroid gland: 31 nTPM

Single-cell type

breast lactating cells: 102 nCPM
bergmann glia: 100 nCPM
schwann cells: 67 nCPM
pericytes: 54 nCPM
vascular smooth muscle cells: 42 nCPM
hepatic stellate cells: 39 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 102 nTPM
medulla oblongata: 28 nTPM
pons: 23 nTPM
spinal cord: 22 nTPM
white matter: 22 nTPM
hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: -0.61
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIMP4 as an antibody target. Whether an autoantibody or antibody against TIMP4 could matter depends on whether native TIMP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIMP4 is annotated as secreted, so native TIMP4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TIMP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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