Seroatlas · Human Serome Atlas

TIMM23B

Mitochondrial import inner membrane translocase subunit Tim23B

Also known as: bA592B15.7, TI23B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5SRD1
Gene
TIMM23B
Ensembl
ENSG00000204152
Chromosome
10
Canonical length
188 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q5SRD1|TIMM23B
     1  MEGGGGSGDK TTGVLAGFFG AGEAGYSHAD LAGVPLTGMN PLCPYLNVDP RYLVQDTDEF
    61  ILPTGANKTW GRFELAFFTI GGCCMTGAAF GAMNGLRLGL KETQNMAWSK PGNVQILNMV
   121  TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTVAA GTMTGMLYKC TVSEMALDSP
   181  FCVLLSGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIMM23B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 17 nTPM
  • bone marrow: 15 nTPM
  • tongue: 14 nTPM
  • heart muscle: 8.9 nTPM
  • skin: 7.2 nTPM
  • blood vessel: 6.4 nTPM

Single-cell type

  • proximal tubule cells: 315 nCPM
  • renal connecting tubule cells: 184 nCPM
  • distal convoluted tubule cells: 184 nCPM
  • renal collecting duct intercalated cells: 159 nCPM
  • loop of henle epithelial cells: 130 nCPM
  • podocytes: 124 nCPM

Immune cell

  • NK-cell: 2.6 nTPM
  • non-classical monocyte: 2.4 nTPM
  • MAIT T-cell: 2 nTPM
  • naive CD4 T-cell: 2 nTPM
  • memory B-cell: 1.5 nTPM
  • myeloid DC: 1.5 nTPM

Brain region

  • medulla oblongata: 14 nTPM
  • pons: 13 nTPM
  • white matter: 12 nTPM
  • hypothalamus: 12 nTPM
  • cerebral cortex: 12 nTPM
  • thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.81
gnomAD pLI
0.13
gnomAD missense Z
0.54

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIMM23B as an antibody target. Whether an autoantibody or antibody against TIMM23B could matter depends on whether native TIMM23B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIMM23B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIMM23B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TIMM23B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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