TIMM17A
Mitochondrial import inner membrane translocase subunit Tim17-A
Also known as: TI17A_HUMAN, TIM17, TIM17A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q99595
- Gene
- TIMM17A
- Ensembl
- ENSG00000134375
- Chromosome
- 1
- Canonical length
- 171 aa
- Protein class
- Cancer-related genes, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Mitochondria
OverviewNCBI Gene
Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial inner membrane and nucleoplasm. Part of TIM23 mitochondrial import inner membrane translocase complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
171 residues, UniProt reviewed canonical sequence.
>Q99595|TIMM17A
1 MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAIKGFRNS PVGVNHRLRG SLTAIKTRAP
61 QLGGSFAVWG GLFSMIDCSM VQVRGKEDPW NSITSGALTG AILAARNGPV AMVGSAAMGG
121 ILLALIEGAG ILLTRFASAQ FPNGPQFAED PSQLPSTQLP SSPFGDYRQY QLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TIMM17A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 3
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 89 nTPM
Expression across tissuesHPA
Tissue
- tongue: 89 nTPM
- skeletal muscle: 81 nTPM
- liver: 75 nTPM
- heart muscle: 68 nTPM
- parathyroid gland: 52 nTPM
- adrenal gland: 47 nTPM
Single-cell type
- syncytiotrophoblasts: 371 nCPM
- extravillous trophoblasts: 243 nCPM
- epididymal principal cells: 215 nCPM
- hepatocytes: 206 nCPM
- migrating cytotrophoblasts: 195 nCPM
- esophageal suprabasal cells: 168 nCPM
Immune cell
- myeloid DC: 50 nTPM
- non-classical monocyte: 47 nTPM
- intermediate monocyte: 45 nTPM
- T-reg: 37 nTPM
- plasmacytoid DC: 34 nTPM
- total PBMC: 32 nTPM
Brain region
- choroid plexus: 29 nTPM
- cerebral cortex: 23 nTPM
- hypothalamus: 22 nTPM
- hippocampal formation: 19 nTPM
- cerebellum: 19 nTPM
- pons: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.68
- gnomAD pLI
- 0.22
- gnomAD missense Z
- 0.49
- DepMap mean gene effect
- -0.24
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- intracellular protein transport
- protein import into mitochondrial matrix
- protein targeting to mitochondrion
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TIMM17A as an antibody target. Whether an autoantibody or antibody against TIMM17A could matter depends on whether native TIMM17A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TIMM17A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TIMM17A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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