Seroatlas · Human Serome Atlas

TIMD4

T-cell immunoglobulin and mucin domain-containing protein 4

Also known as: TIM4, TIMD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96H15
Gene: TIMD4
Ensembl: ENSG00000145850
Chromosome: 5
Canonical length: 378 aa
Protein class: Plasma proteins, Predicted membrane proteins
Subcellular location: Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable phosphatidylserine binding activity. Predicted to be involved in apoptotic cell clearance and cytoskeletal rearrangement involved in phagocytosis, engulfment. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>Q96H15|TIMD4
     1  MSKEPLILWL MIEFWWLYLT PVTSETVVTE VLGHRVTLPC LYSSWSHNSN SMCWGKDQCP
    61  YSGCKEALIR TDGMRVTSRK SAKYRLQGTI PRGDVSLTIL NPSESDSGVY CCRIEVPGWF
   121  NDVKINVRLN LQRASTTTHR TATTTTRRTT TTSPTTTRQM TTTPAALPTT VVTTPDLTTG
   181  TPLQMTTIAV FTTANTCLSL TPSTLPEEAT GLLTPEPSKE GPILTAESET VLPSDSWSSV
   241  ESTSADTVLL TSKESKVWDL PSTSHVSMWK TSDSVSSPQP GASDTAVPEQ NKTTKTGQMD
   301  GIPMSMKNEM PISQLLMIIA PSLGFVLFAL FVAFLLRGKL METYCSQKHT RLDYIGDSKN
   361  VLNDVQHGRE DEDGLFTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIMD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 137 nTPM

Expression across tissuesHPA

Tissue

testis: 137 nTPM
lymph node: 52 nTPM
thymus: 21 nTPM
tonsil: 16 nTPM
liver: 15 nTPM
bone marrow: 15 nTPM

Single-cell type

late spermatids: 2,824 nCPM
early spermatids: 1,393 nCPM
late primary spermatocytes: 656 nCPM
kupffer cells: 350 nCPM
hofbauer cells: 126 nCPM
renal collecting duct intercalated cells: 72 nCPM

Immune cell

T-reg: 4 nTPM
memory CD8 T-cell: 2.5 nTPM
naive CD4 T-cell: 1.6 nTPM
naive CD8 T-cell: 1.6 nTPM
memory CD4 T-cell: 1.3 nTPM
total PBMC: 0.7 nTPM

Brain region

choroid plexus: 3.5 nTPM
cerebral cortex: 2.6 nTPM
pons: 0.8 nTPM
thalamus: 0.8 nTPM
hippocampal formation: 0.7 nTPM
medulla oblongata: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

apoptotic cell clearance
cytoskeletal rearrangement involved in phagocytosis, engulfment

Molecular functions

phosphatidylserine binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TIMD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIMD4 as an antibody target. Whether an autoantibody or antibody against TIMD4 could matter depends on whether native TIMD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIMD4 is annotated at the cell surface, where native TIMD4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TIMD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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