Seroatlas · Human Serome Atlas

THYN1

Thymocyte nuclear protein 1

Also known as: THY28, THYN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P016
Gene: THYN1
Ensembl: ENSG00000151500
Chromosome: 11
Canonical length: 225 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q9P016|THYN1
     1  MSRPRKRLAG TSGSDKGLSG KRTKTENSGE ALAKVEDSNP QKTSATKNCL KNLSSHWLMK
    61  SEPESRLEKG VDVKFSIEDL KAQPKQTTCW DGVRNYQARN FLRAMKLGEE AFFYHSNCKE
   121  PGIAGLMKIV KEAYPDHTQF EKNNPHYDPS SKEDNPKWSM VDVQFVRMMK RFIPLAELKS
   181  YHQAHKATGG PLKNMVLFTR QRLSIQPLTQ EEFDFVLSLE EKEPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THYN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

thymus: 72 nTPM
epididymis: 72 nTPM
cerebral cortex: 71 nTPM
amygdala: 69 nTPM
basal ganglia: 68 nTPM
ovary: 66 nTPM

Single-cell type

oocytes: 824 nCPM
decidual stromal cells: 109 nCPM
undifferentiated spermatogonia: 103 nCPM
early primary spermatocytes: 81 nCPM
ovarian stromal cells: 77 nCPM
differentiating spermatogonia: 77 nCPM

Immune cell

eosinophil: 331 nTPM
naive CD8 T-cell: 201 nTPM
T-reg: 200 nTPM
basophil: 186 nTPM
MAIT T-cell: 176 nTPM
naive CD4 T-cell: 176 nTPM

Brain region

hypothalamus: 40 nTPM
white matter: 40 nTPM
cerebral cortex: 39 nTPM
basal ganglia: 38 nTPM
cerebellum: 36 nTPM
pons: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

PUA-like superfamily
EVE domain
Thymocyte nuclear protein 1-like, EVE domain
5-Hydroxymethylcytosine binding
EVE domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THYN1 as an antibody target. Whether an autoantibody or antibody against THYN1 could matter depends on whether native THYN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THYN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THYN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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