Seroatlas · Human Serome Atlas

THTPA

Thiamine-triphosphatase

Also known as: THTPA_HUMAN, THTPASE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BU02
Gene: THTPA
Ensembl: ENSG00000259431
Chromosome: 14
Canonical length: 230 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>Q9BU02|THTPA
     1  MAQGLIEVER KFLPGPGTEE RLQELGGTLE YRVTFRDTYY DTPELSLMQA DHWLRRREDS
    61  GWELKCPGAA GVLGPHTEYK ELTAEPTIVA QLCKVLRADG LGAGDVAAVL GPLGLQEVAS
   121  FVTKRSAWKL VLLGADEEEP QLRVDLDTAD FGYAVGEVEA LVHEEAEVPT ALEKIHRLSS
   181  MLGVPAQETA PAKLIVYLQR FRPQDYQRLL EVNSSRERPQ ETEDPDHCLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THTPA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

amygdala: 25 nTPM
cerebral cortex: 24 nTPM
skeletal muscle: 23 nTPM
hippocampal formation: 21 nTPM
basal ganglia: 21 nTPM
choroid plexus: 20 nTPM

Single-cell type

other brain neurons: 11 nCPM
oligodendrocytes: 10 nCPM
bergmann glia: 10 nCPM
brain excitatory neurons: 8.5 nCPM
astrocytes: 8.3 nCPM
brain inhibitory neurons: 8.3 nCPM

Immune cell

plasmacytoid DC: 19 nTPM
non-classical monocyte: 16 nTPM
classical monocyte: 16 nTPM
naive B-cell: 15 nTPM
myeloid DC: 15 nTPM
basophil: 14 nTPM

Brain region

cerebral cortex: 57 nTPM
amygdala: 31 nTPM
white matter: 30 nTPM
choroid plexus: 30 nTPM
medulla oblongata: 30 nTPM
basal ganglia: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

dephosphorylation
generation of precursor metabolites and energy
thiamine diphosphate biosynthetic process
thiamine metabolic process
thiamine diphosphate metabolic process

Molecular functions

hydrolase activity
magnesium ion binding
thiamine triphosphate phosphatase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Thiamine triphosphatase, eukaryotes
CYTH domain
CYTH-like domain superfamily
Thiamine-triphosphatase
CYTH domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THTPA as an antibody target. Whether an autoantibody or antibody against THTPA could matter depends on whether native THTPA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THTPA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THTPA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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