Seroatlas · Human Serome Atlas

THSD8

Thrombospondin type-1 domain-containing protein 8

Also known as: THSD8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1W2PP97
Gene
THSD8
Ensembl
ENSG00000284491
Chromosome
19
Canonical length
115 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for THSD8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>A0A1W2PP97|THSD8
     1  MARTPGALLL APLLLLQLAT PALVYQDYQY LGQQGEGDSW EQLRLQHLKE VEDSILGPWG
    61  KWRCLCDLGK QERSREVVGT APGPVFMDPE KLIQLRPCRQ RDCPSCKPFD CDWRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THSD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
0.3 nTPM

Expression across tissuesHPA

Tissue

  • skin: 0.3 nTPM
  • testis: 0.3 nTPM
  • salivary gland: 0.1 nTPM
  • small intestine: 0.1 nTPM
  • thyroid gland: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • breast myoepithelial cells: 94 nCPM
  • prostatic hillock cells: 22 nCPM
  • neutrophils: 12 nCPM
  • colonocytes: 12 nCPM
  • salivary myoepithelial cells: 12 nCPM
  • prostatic club cells: 8.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 0.3 nTPM
  • white matter: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebellum: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THSD8 as an antibody target. Whether an autoantibody or antibody against THSD8 could matter depends on whether native THSD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THSD8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THSD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THSD8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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