Seroatlas · Human Serome Atlas

THSD7B

Thrombospondin type-1 domain-containing protein 7B

Also known as: KIAA1679, THS7B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C0I4
Gene
THSD7B
Ensembl
ENSG00000144229
Chromosome
2
Canonical length
1606 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in actin cytoskeleton organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1606 residues, UniProt reviewed canonical sequence.

>Q9C0I4|THSD7B
     1  MFPKSNLTVT CWVWRSMRKL FLLLSLLLSH AAHLEGKKDN QFIWKPGPWG RCTGDCGPGG
    61  VQSRAVWCFH VDGWTSHLSN CGESNRPPKE RSCFRVCDWH SDLFQWEVSD WHHCVLVPYA
   121  RGEVKPRTAE CVTAQHGLQH RMVRCIQKLN RTVVANEICE HFALQPPTEQ ACLIPCPRDC
   181  VVSEFLPWSN CSKGCGKKLQ HRTRAVIAPP LFGGLQCPNL TESRACDAPI SCPLGEEEYT
   241  FSLKVGPWSK CRLPHLKEIN PSGRTVLDFN SDSNERVTFK HQSYKAHHHS KSWAIEIGYQ
   301  TRQVSCTRSD GQNAMLSLCL QDSFPLTVQS CIMPKDCETS QWSSWSPCSK TCRSGSLLPG
   361  FRSRSRNVKH MAIGGGKECP ELLEKEACIV EGELLQQCPR YSWRTSEWKE CQVSLLLEQQ
   421  DPHWHVTGPV CGGGIQTREV YCAQSVPAAA ALRAKEVSRP VEKALCVGPA PLPSQLCNIP
   481  CSTDCIVSSW SAWGLCIHEN CHDPQGKKGF RTRQRHVLME STGPAGHCPH LVESVPCEDP
   541  MCYRWLASEG ICFPDHGKCG LGHRILKAVC QNDRGEDVSG SLCPVPPPPE RKSCEIPCRM
   601  DCVLSEWTEW SSCSQSCSNK NSDGKQTRSR TILALAGEGG KPCPPSQALQ EHRLCNDHSC
   661  MQLHWETSPW GPCSEDTLVT ALNATIGWNG EATCGVGIQT RRVFCVKSHV GQVMTKRCPD
   721  STRPETVRPC FLPCKKDCIV TAFSEWTPCP RMCQAGNATV KQSRYRIIIQ EAANGGQECP
   781  DTLYEERECE DVSLCPVYRW KPQKWSPCIL VPESVWQGIT GSSEACGKGL QTRAVSCISD
   841  DNRSAEMMEC LKQTNGMPLL VQECTVPCRE DCTFTAWSKF TPCSTNCEAT KSRRRQLTGK
   901  SRKKEKCQDS DLYPLVETEL CPCDEFISQP YGNWSDCILP EGRREPHRGL RVQADSKECG
   961  EGLRFRAVAC SDKNGRPVDP SFCSSSGYIQ EKCVIPCPFD CKLSDWSSWG SCSSSCGIGV
  1021  RIRSKWLKEK PYNGGRPCPK LDLKNQVHEA VPCYSECNQY SWVVEHWSSC KINNELRSLR
  1081  CGGGTQSRKI RCVNTADGEG GAVDSNLCNQ DEIPPETQSC SLMCPNECVM SEWGLWSKCP
  1141  QSCDPHTMQR RTRHLLRPSL NSRTCAEDSQ VQPCLLNENC FQFQYNLTEW STCQLSENAP
  1201  CGQGVRTRLL SCVCSDGKPV SMDQCEQHNL EKPQRMSIPC LVECVVNCQL SGWTAWTECS
  1261  QTCGHGGRMS RTRFIIMPTQ GEGRPCPTEL TQEKTCPVTP CYSWVLGNWS ACKLEGGDCG
  1321  EGVQIRSLSC MVHSGSISHA AGRVEDALCG EMPFQDSILK QLCSVPCPGD CHLTEWSEWS
  1381  TCELTCIDGR SFETVGRQSR SRTFIIQSFE NQDSCPQQVL ETRPCTGGKC YHYTWKASLW
  1441  NNNERTVWCQ RSDGVNVTGG CSPQARPAAI RQCIPACRKP FSYCTQGGVC GCEKGYTEIM
  1501  KSNGFLDYCM KVPGSEDKKA DVKNLSGKNR PVNSKIHDIF KGWSLQPLDP DGRVKIWVYG
  1561  VSGGAFLIMI FLIFTSYLVC KKPKPHQSTP PQQKPLTLAY DGDLDM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THSD7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • retina: 18 nTPM
  • epididymis: 3.9 nTPM
  • adipose tissue: 1.8 nTPM
  • blood vessel: 1.8 nTPM
  • ovary: 1.1 nTPM
  • fallopian tube: 0.9 nTPM

Single-cell type

  • retinal horizontal cells: 1,923 nCPM
  • rod photoreceptor cells: 1,774 nCPM
  • cone photoreceptor cells: 849 nCPM
  • adipocytes: 210 nCPM
  • prostatic glandular cells: 183 nCPM
  • brain inhibitory neurons: 165 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 19 nTPM
  • medulla oblongata: 10 nTPM
  • midbrain: 7.5 nTPM
  • hypothalamus: 5.3 nTPM
  • white matter: 3.6 nTPM
  • cerebral cortex: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
0.74

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THSD7B as an antibody target. Whether an autoantibody or antibody against THSD7B could matter depends on whether native THSD7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THSD7B is annotated at the cell surface, where native THSD7B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label THSD7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THSD7B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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