Seroatlas · Human Serome Atlas

THOP1

Thimet oligopeptidase

Also known as: THOP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P52888
Gene
THOP1
Ensembl
ENSG00000172009
Chromosome
19
Canonical length
689 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

689 residues, UniProt reviewed canonical sequence.

>P52888|THOP1
     1  MKPPAACAGD MADAASPCSV VNDLRWDLSA QQIEERTREL IEQTKRVYDQ VGTQEFEDVS
    61  YESTLKALAD VEVTYTVQRN ILDFPQHVSP SKDIRTASTE ADKKLSEFDV EMSMREDVYQ
   121  RIVWLQEKVQ KDSLRPEAAR YLERLIKLGR RNGLHLPRET QENIKRIKKK LSLLCIDFNK
   181  NLNEDTTFLP FTLQELGGLP EDFLNSLEKM EDGKLKVTLK YPHYFPLLKK CHVPETRRKV
   241  EEAFNCRCKE ENCAILKELV TLRAQKSRLL GFHTHADYVL EMNMAKTSQT VATFLDELAQ
   301  KLKPLGEQER AVILELKRAE CERRGLPFDG RIRAWDMRYY MNQVEETRYC VDQNLLKEYF
   361  PVQVVTHGLL GIYQELLGLA FHHEEGASAW HEDVRLYTAR DAASGEVVGK FYLDLYPREG
   421  KYGHAACFGL QPGCLRQDGS RQIAIAAMVA NFTKPTADAP SLLQHDEVET YFHEFGHVMH
   481  QLCSQAEFAM FSGTHVERDF VEAPSQMLEN WVWEQEPLLR MSRHYRTGSA VPRELLEKLI
   541  ESRQANTGLF NLRQIVLAKV DQALHTQTDA DPAEEYARLC QEILGVPATP GTNMPATFGH
   601  LAGGYDAQYY GYLWSEVYSM DMFHTRFKQE GVLNSKVGMD YRSCILRPGG SEDASAMLRR
   661  FLGRDPKQDA FLLSKGLQVG GCEPEPQVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THOP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • liver: 72 nTPM
  • testis: 68 nTPM
  • cerebral cortex: 60 nTPM
  • hippocampal formation: 53 nTPM
  • amygdala: 53 nTPM
  • cerebellum: 50 nTPM

Single-cell type

  • enterocytes: 281 nCPM
  • colonocytes: 127 nCPM
  • hepatocytes: 100 nCPM
  • late primary spermatocytes: 67 nCPM
  • extravillous trophoblasts: 64 nCPM
  • goblet cells: 60 nCPM

Immune cell

  • basophil: 9.1 nTPM
  • T-reg: 7.6 nTPM
  • plasmacytoid DC: 7 nTPM
  • non-classical monocyte: 6 nTPM
  • naive B-cell: 5.3 nTPM
  • memory CD8 T-cell: 5.2 nTPM

Brain region

  • medulla oblongata: 39 nTPM
  • cerebral cortex: 39 nTPM
  • hippocampal formation: 38 nTPM
  • midbrain: 36 nTPM
  • basal ganglia: 35 nTPM
  • pons: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
1.47
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THOP1 as an antibody target. Whether an autoantibody or antibody against THOP1 could matter depends on whether native THOP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THOP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THOP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THOP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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